The second edition of The Compleat Pediatrician was reviewed favorably irn the YALE JOURNAL OF BIOLOGY AND MEDICINE in October, 1938. A third edition of this unique pediatric manual is now at hand. To keep "symptoms and signs as clues" and therapeutic procedures in pediatric practice abreast of the facts and experience acquired during the past three years, it has been necessary to make changes ...

Rhesus monkeys self-administered ethanol intravenously during daily, 3-h sessions. When ethanol-reinforced responding was stable and ethanol intake was in the range of 2.6-3.6 g/kg/3 h, physiological dependence to ethanol was induced by daily passive infusions of additional ethanol. In less than 1 week, mild to moderate withdrawal signs were observed prior to daily sessions. Ethanol intake was ...

Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The clinical, Paraclinical and pathological findings in 50 biopsy proven patients with DLE referre...

The impact of many intensive care unit interventions has not been fully quantified, especially in heterogeneous patient populations. We train unsupervised switching state autoregressive models on vital signs from the public MIMIC-III database to capture patient movement between physiological states. We compare our learned states to static demographics and raw vital signs in the prediction of fi...

Inadequate design and poor user-interface are given as reasons for unsuccessful implementation of electronic health records (EHR) [1,2]. However, rather than designing more suitable technology, the trend has been to 'muddle through' [2] and to urge health care workers to adapt to poorly designed systems [3]. This may work to some degree but little is known about the impact this could have on pa...

In as much as Hussain et al. in their article, Brainstem ischemia in acute herniation syndrome [1], like Ritter et al. [2] in Brain stem blood flow, pupillary response and outcome in patients with severe head injuries have argued in favor of an alternative explanation (vascular, as opposed to mechanical) for the clinical findings in those with expanding hemispheric lesions, i.e. the presence of...

So far inferences on early moral development and higher order self conscious emotions have mostly been based on behavioral data. Emotions though, as far as arguments support, are multidimensional notions. Not only do they involve behavioral actions upon perception of an event, but they also carry autonomic physiological markers. The current study aimed to examine and characterise physiological ...

In this paper we develop a Hierarchical Switching Linear Dynamical System (HSLDS) for the detection of sepsis in neonates in an intensive care unit. The Factorial Switching LDS (FSLDS) of Quinn et al. (2009) is able to describe the observed vital signs data in terms of a number of discrete factors, which have either physiological or artifactual origin. In this paper we demonstrate that by addin...