Polyphotocages In article number 2300780, Wen Sun, Peiyuan Wang, and co-workers report a drug delivery platform based on Ru complex containing polyphotocage which is prepared through photocage-polymer hybrid macromolecular engineering. Red light irradiation of the triggers breakage coordination bond between complexes anticancer drugs, releases drugs for photochemotherapy precisely.

The treatment of sclerosing skin diseases [systemic sclerosis, localized scleroderma, lichen sclerosus et atrophicus, sclerodermoid graft-vs.-host disease, scleredema adultorum (Buschke), scleromyxedema and necrobiosis lipoidica] is difficult and remains a great challenge. Numerous treatments, some with potentially hazardous side effects, are currently used with only limited success. The introd...

Abstract Immunotherapy has made great progress in recent years while most cancer patients cannot benefit from it. Photochemotherapy combination strategy holds promise for developing novel immunotherapy the bearing immunosuppressive tumors such as colon cancer. In this research, a core/shell-structured polydopamine (PDA)-based nanoplatform is constructed to load two Food and Drug Administration ...

8-methoxypsoralen (8-MOP), activated upon exposure to long-wavelength ultraviolet radiation, is used therapeutically to treat the diseased blood cells of cutaneous T-cell lymphoma patients. The factors responsible for the efficacy of this therapy are reviewed. Primary among these are the plasma level of 8-MOP at the time of irradiation and the effective dose of UVA. 8-MOP plasma levels determin...

OBJECTIVE To develop and introduce evidence-based guidelines for the selection of 5 commonly used treatment modalities--UV-B, photochemotherapy, methotrexate, acitretin, and cyclosporine--for adult patients with severe plaque form psoriasis. PATIENTS AND SETTING Patients, residents, and dermatologists from the Department of Dermatology of the Academic Medical Center of the University of Amste...