Background: Thalidomide has caused thalidomide embryopathy (TE) in more than 10,000 live-born children and is typically associated with phocomelia as well several other abnormalities such eye or ear malformations internal organ defects. Nowadays, survivors entered middle age, an age that susceptible to breast cancer women.

a 39-year-old pregnant woman at 38 weeks of gestation was referred with labor pain to a hospital. she had consanguinity with her husband. a female newborn had multiple craniofacial anomalies and phocomelia in right upper limb. the disease locus was assigned to chromosome17q21. four days later, infant died of cardiopulmonary arrest.