The Saccharomyces cerevisiae genes KAR/ and CDC31 are required for the initial stages of spindie pole body (SPB) duplication in yeast. The Cdc31 protein is most related to caltractin/centrin, a calciumbinding protein present in microtubule organizing centers in many organisms. Because of a variety of genetic interactions between CDC31 and KARl (VaUen, E. A., W. Ho, M. Winey, and M. D. Rose. 199...

Surfactant derived protein B (SPB) and plasma receptor for advanced glycation end products (RAGE) have been proposed as markers of lung injury. The former is produced specifically by pneumocytes while RAGE production is present in several body tissues. Cardiopulmonary bypass (CPB) generates a transient lung injury. We measured SPB and RAGE in plasma before surgery and after CPB, as well as 24 h...

Slow-paced breathing (SPB) is a well-known relaxation technique in athletes, which has also the potential to help optimize addiction treatments based on its effects autonomic nervous system. Specifically, these directly impact cardiac vagal activity (CVA), of vagus nerve regulating functioning. The long-term SPB interventions CVA have already received some attention; however, single session sti...

KAR1 encodes an essential component of the yeast spindle pole body (SPB) that is required for karyogamy and SPB duplication. A temperature-sensitive mutation, kar1-delta 17, mapped to a region required for SPB duplication and for localization to the SPB. To identify interacting SPB proteins, we isolated 13 dominant mutations and 3 high copy number plasmids that suppressed the temperature sensit...

BACKGROUND Prostate cancer (PCa) is a leading cause of cancer-related death in men. Sodium phenylbutyrate (SPB) has shown its potential as an anticancer therapy in numerous cancer types. In the present study, we attempted to assess the effect of SPB against PCa and whether this treatment was associated with the regulation of survivin. METHODS Two human PCa cancer cell lines, DU145 and PC3, we...

Prenatal ethanol exposure can lead to long-lasting impairments in the ability of rats to process spatial information, as well as produce long-lasting deficits in long-term potentiation (LTP), a biological model of learning and memory processing. The present study aimed to examine the sexually dimorphic effects of chronic prenatal ethanol exposure (CPEE) on behavior cognition and synaptic plasti...

Abstract The mechanism of the seasonal persistence barrier (SPB) is studied in framework an autoregressive (AR) model. In contrast to variance, whose minimum modulated mainly by growth rate or noise forcing, SPB caused primarily declining increasing instead minimum/maximum forcing. other words, signal-to-noise ratio (SNR) rather than weakest SNR. a weakly damped system, phase delayed from that ...

Aims. In order to better model massive B-type stars, we need to understand the physical processes taking place in slowly pulsating B (SPB) stars, chemically peculiar Bp stars, and non-pulsating normal B stars co-existing in the same part of the H-R diagram. Methods. We carry out a comparative study between samples of confirmed and well-studied SPB stars and a sample of well-studied Bp stars wit...

The yeast spindle pole body (SPB) is the functional equivalent of the centrosome. Most SPB components have been identified and their functions partly established. This involved a large variety of techniques which are described here, and the potential use of some of these in the centrosome field is highlighted. In particular, very useful structural information on the SPB was obtained from a reco...

BACKGROUND The spindle pole body (SPB) of budding yeast is the functional equivalent of the mammalian centrosome. Like the centrosome, the SPB duplicates once per cell cycle. The new SPB assembles adjacent to the mother SPB at a substructure called the bridge. The half-bridge, the bridge precursor, is a one-sided extension of the SPB central plaque layered on both sides of the nuclear envelope....