This article discusses the relative contraindications to the use of vasoconstrictor in patients currently medicated with tricyciic antidepressants, monoamine oxidase inhibitors, phenothiazines and P-blockers. It reviews drug interactions and emphasizes potential detrimental systemic effects that epinephrine contained in !ocal anesthetics can have when administered concomitantly with these drugs...

BACKGROUND Although pharmacologic stress myocardial perfusion imaging (MPI) and exercise stress MPI have comparable diagnostic accuracy, their comparative value for risk stratification of patients with known or suspected coronary disease is not known. METHODS AND RESULTS The data of 14,918 patients were combined from 24 studies evaluating prognosis in patients undergoing either pharmacologic ...

Opsoclonus-myoclonus is a pervasive neurological syndrome of children and adults. Although rare, it raises important clinical and neurobiological issues. This article provides an overview of the clinical and laboratory features, differential diagnosis, treatment, and outcome of opsoclonus-myoclonus. It pursues immunologic, genetic, electrophysiologic, neurochemical, and other clues to a pharmac...