An asymmetrical FIA merging-zones manifold based on the dual injection of two sample microvolumes was developed for the simultaneous determination of salicylic acid and acetylsalicylic acid in pharmaceutical preparations at a sampling frequency of 30/h. The complex formed between the Fe(III) reagent continuously introduced in the system and salicylic acid was monitored photometrically at 520 nm...

Having validated analysis methods for medicinal ingredients is attractive for pharmaceutical companies. When a new molecule is introduced to the market, there is not any pharmacopeial analysis method for that. After publishing official methods, correlation between validated in-house methods and the official one could stablish the value of the in-house method. Sitagliptin phosphate is a new anti...

The dramatic growth of research and development activities in the pharmaceutical sector in emerging economies raises the question of whether the United States still keeps its dominant role in the global pharmaceutical innovation landscape. This paper focuses on investigating the role of the United States in global pharmaceutical innovation, and differs from previous studies by shifting attentio...

Cross-sectional survey study was done, investigating whether information included in SmPC (changing often due to safety reasons) is actually used, properly used or not used at all by cardiologists, GP's (general practitioners), internists and internal diseases physicians. Conducting readability test of Patient Information Leaflet, required by European Commission improved utilization of medical ...

In recent years, as more generic drug products become available, it is a concern not only whether generic drug products that have been approved based on the regulation of average bioequivalence will have the same quality, safety and efficacy as that of the brand-name drug product, but also whether the approved generic drug products can be used interchangeably. In its recent draft guidance, the ...

OBJECTIVE The study aimed to determine the type of professional and non professional work of community pharmacists in Surabaya Indonesia and find the difference between time spent for performing both works in actual (current) situation and ideal (expected) situation. METHODS A cross sectional study was conducted by combining purposive sampling for selecting the community pharmacists. Afterwar...

OBJECTIVE To systematically assess the clinical effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis by meta-analysis. METHODS The articles were mainly retrieved from the "CHKD (China Hospital Knowledge Database) periodical full text databank", the "China periodical full text databank", the "CHKD doctor's and Master's degree student full text databank", and...

OBJECTIVES To assess the completeness of reporting of sample size determinations in unpublished research protocols and to develop guidance for research ethics committees and for statisticians advising these committees. DESIGN Review of original research protocols. STUDY SELECTION Unpublished research protocols for phase IIb, III, and IV randomised clinical trials of investigational medicina...

BACKGROUND There is growing evidence about illicit use of buprenorphine in the U.S. The study aims to: (1) identify prevalence and predictors of illicit buprenorphine use in a community sample of 396 young adult (18-23 years old) non-medical users of pharmaceutical opioids and (2) describe knowledge, attitudes and behaviors linked to illicit buprenorphine use as reported by a qualitative sub-sa...