after the boom of pharmacological research during the 1950s, mainly as a result of the screening technique, the identification of active molecules, their reshaping by means of pharmaco-chemical drug design, and the creation of extremely efficacious and successful medicines, the pharmaceutical world sought a new source of inspiration. such biota as the tropical forest, a quantity of plants credi...

materials and methods the expression of hyaluronidase antigenic fragments was optimized using iptg concentration, time of induction, temperature, culture, and absorbance of 0.6-0.8-1 at 600 nm. afterwards, the expressed proteins were purified and the enzymatic activity was assessed by turbid metric method. results data indicated that maximum protein is produced in od = 0.8, 0.5 mm isopropyl β-d...

interaction of drugs with serum albumin, the most abundant protein in plasma, has a great significance in pharmaceutical sciences. it can affect the biological activity, toxicity, and pharmacokinetics of drugs and design of dosages. determination of the impact of chemical modifications of albumin and its structural changes upon interaction with drugs are very important when drugs bind with albu...

Seaweeds have been introduced as an important sources of food and pharmaceutical active agents since last century. In this study, the chemical composition and functional characteristics of (common names) Nizamuddinia zanardinii and Iyengaria stellata, were investigated. The total carbohydrate and ash contents were the two most abundant components in these seaweeds but their crude lipid and fibe...

background and objectives: pharmaceutical expenditures are responsible for a major part of health systems’ cost. according to the who’s statistics, iran is the first among the 20 countries in the world in terms of drug consumption. the first step in controlling consumption of a particular good is to identify factor inducing the relevant demands. hence, this study aimed to identify the pattern a...

In recent years, the number of recombinant proteins used for therapeutic applications and industry has increased dramatically. Recombinant proteins are produced in many host organisms (microbial, insect, plant and mammalian cells). There are many factors to consider when choosing the optimal system for protein expression and purification including the mass, purity or solubility of the recombina...

In the early 80 of the last century molecular modeling was introduced as a tool to aid rational drug design in pharmaceutical industry. However in these early days modeling had narrow limits due to the lack of adequate compute power and sophisticated methods. There was a large gap between expectations of medicinal chemists and the power of theoretical methods. Today computational chemistry is a...