In this study, the optimal conditions for the extraction of antioxidants from the Buah Mahkota Dewa fruit (Phaleria macrocarpa) was determined by using Response Surface Methodology (RSM). The optimisation was applied using a Central Composite Design (CCD) to investigate the effect of three independent variables, namely extraction temperature (°C), extraction time (minutes) and extraction solven...

This study aimed to determine the antioxidant activity and potential cytotoxicity effects of crude ethanol extract Mahkota Dewa (Phaleria macrocarpa) leaves on breast cancer cell lines. The P. macrocarpa was carried out by 2,2-diphenylpicrylhydrazyl (DPPH) assay. total phenolic flavonoid contents were evaluated using Folin-ciocalteu aluminium chloride methods, respectively. cytotoxic effect lin...

Objective(s):This study was designed to investigate the effect of Phaleria macrocarpa aqueous extract (PM) on spermatogenesis by observing the histological changes of testes in adult male rats. Materials and Methods: PM was prepared by boiling the dried slices of P. macrocarpa fruits followed by filtering, centrifugation and freeze-drying to obtain the powder form. Eighteen Sprague Dawley adult...

Extracts of Phaleria macrocarpa have been used for years in traditional medicine and evaluated scientifically as well. This study aimed to evaluate the chronic toxicity level nano herbal its effect on changes hematology, biochemistry, electrolytes, organ histopathology. High Energy Milling (HEM) produced . By giving at doses 300, 600, 900 mg/kg BW 56 days, mice’s blood was collected hematologic...

Phaleria macrocarpa leaves have the potential to be used as raw materials for medicines derived from natural ingredients, but research is needed determine content and efficacy of these plants. This study aims analyze yield screening phytochemical compounds in ethanolic extract leaves. a descriptive study. Extract analysis was performed by calculating weight ratio divided simplicia multiplied on...

OBJECTIVES This study was designed to investigate the effect of Phaleria macrocarpa aqueous extract (PM) on spermatogenesis by observing the histological changes of testes in adult male rats. MATERIALS AND METHODS PM was prepared by boiling the dried slices of P. macrocarpa fruits followed by filtering, centrifugation and freeze-drying to obtain the powder form. Eighteen Sprague Dawley adult ...

In vitro and in vivo studies of the activity of Phaleria macrocarpa Boerl (Thymelaeaceae) leaves against the therapeutic target for hypercholesterolemia were done using the HDL receptor (SR-BI) and hypercholesterolemia-induced Sprague Dawley rats. The in vitro study showed that the active fraction (CF6) obtained from the ethyl acetate extract (EMD) and its component 2',6',4-trihydroxy-4'-methox...