نتایج جستجو برای: pgr

تعداد نتایج: 1018  

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007
Paul E Goss James N Ingle Silvana Martino Nicholas J Robert Hyman B Muss Martine J Piccart Monica Castiglione Dongsheng Tu Lois E Shepherd Kathleen I Pritchard Robert B Livingston Nancy E Davidson Larry Norton Edith A Perez Jeffrey S Abrams David A Cameron Michael J Palmer Joseph L Pater

PURPOSE Controversy exists regarding estrogen (ER) and progesterone (PgR) receptor expression on efficacy of adjuvant endocrine therapy. In the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial, the benefit of anastrozole over tamoxifen was substantially greater in ER+/PgR-than ER+/PgR+ tumors. In BIG 1-98 (Breast International Group), the benefits of letrozole over tamoxifen were the s...

1989
John A. Foekens Henk Portengen Wim L. J. van Putten Harry A. Peters Hendrik L. J. M. Krijnen Jana Alexieva-Figusch Jan G. M. Klijn

Clinically significant cut-off values to discriminate between receptorpositive and -negative, and the prognostic value of estrogen receptors (ER) and progesterone receptors (PgR) measured by enzyme immunoassay (EIA) have not yet been established. We have therefore measured ER and PgR by EIA in cytosols from 205 primary breast cancer biopsies. Clinically significant cut-off values (30 fmol/mg pr...

Journal: :Cancer research 1980
R Romić-Stojković S Gamulin

The qualitative and quantitative relationships between cytoplasmic estrogen receptors (ERC), total nuclear estrogen receptors (ERN), and cytoplasmic progesterone receptors (PGR) in 74 primary and 23 metastatic human breast cancer tissues were studied. A positive correlation between the age of th patients and the receptor concentration was found only for ERC. Although ERN and PGR were more frequ...

Journal: :The Journal of Cell Biology 1980
S Z Haslam G Shyamala

The biological basis for the observed modulation in cytoplasmic progesterone receptors (PgR) of normal mammary gland occurring during mammary development was investigated. Specifically, the relative roles of hormones vs. differentiation on (a) the decrease in PgR concentration during pregnancy and lactation and (b) the loss of mammary responsiveness to estrogen during lactation were examined. P...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1999
V C Lin E H Ng S E Aw M G Tan V S Chan G H Ho

Because progesterone exerts its effects mainly via estrogen-dependent progesterone receptor (PgR), the expression of progesterone's effects may be overshadowed by the priming effect of estrogen. PgR expression vectors were transfected into estrogen receptor (ER)-alpha and PgR-negative breast cancer cells MDA-MB-231; thus the functions of progesterone could be studied independent of estrogens an...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1995
L C Murphy S G Hilsenbeck H Dotzlaw S A Fuqua

To gain insight into the possible biological role of variant estrogen receptor (ER) expression in human breast cancer, we have undertaken a study to determine if the expression of the clone 4 variant ER mRNA was associated with markers of either reduced endocrine sensitivity [i.e., progesterone receptor (PgR) negativity] or a poor prognosis (node positivity, large tumor size, and high percentag...

Journal: :Endocrinology 2012
Namrata Bali Jason M Arimoto Nahoko Iwata Sharon W Lin Liqin Zhao Roberta D Brinton Todd E Morgan Caleb E Finch

Progesterone (P4) and estradiol (E2) modulate neurogenesis and synaptic remodeling in the hippocampus during the rat estrous cycle and in response to deafferenting lesions, but little is known about the steroidal regulation of hippocampal progesterone receptors associated with these processes. We examined the neuronal expression of progesterone receptor membrane component-1 (Pgrmc1) and the cla...

Journal: :Experimental and therapeutic medicine 2012
Tomofumi Osako Reiki Nishimura Yasuhiro Okumura Yasuo Toyozumi Nobuyuki Arima

Estrogen receptor (ER) and progesterone receptor (PgR) status are predictive factors for the clinical and pathological response to neoadjuvant chemotherapy for operable breast cancer. However, it remains unclear as to how the proportion of ER-positive or PgR-positive tumor cells affects the response to neoadjuvant chemotherapy. We examined the correlation of the proportion of ER-positive or PgR...

Journal: :Molecules 2015
Estefania Hugo Jael Reyes Elisa Montupil Raquel Bridi Eduardo Lissi Ana Denicola María Angélica Rubio Camilo López-Alarcón

In the present work we studied the reaction under gastric conditions of pyrogallol red (PGR), a polyphenolic dye, with nitrous acid (HONO). PGR has been used as a model polyphenol due to its strong UV-visible absorption and its high reactivity towards reactive species (radicals and non-radicals, RS). The reaction was followed by UV-visible spectroscopy and high performance liquid chromatography...

Journal: :Cancer research 1990
A Reiner B Neumeister J Spona G Reiner M Schemper R Jakesz

An immunocytochemical assay (ICA) for the measurement of estrogen receptor (ER) and progesterone receptor (PgR) has been evaluated in 426 human primary breast carcinomas. For estrogen receptor determination ER ICA was used. PgR ICA was performed using the monoclonal antibody KD 68. Assay results for progesterone receptor immunocytochemistry were in agreement (P less than 0.0001) with those of b...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید