The effect of 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), a nitric oxide (NO) scavenger that yields nitrogen dioxide (NO(2)) in a rat endotoxemia model was investigated. Endotoxin (lipopolysaccharide [LPS]) increased NO synthase (NOS) activity and inducible NOS expression measured in lung and plasma levels of nitrite/nitrate, 6-oxo-prostaglandin (PG) F(1alpha), th...

Applications of participatory mapping (PMapping) and PGIS to the local spatial knowledge are expanding; therefore, updated ethics good practice improvements needed. The intention here is secern, or distinguish between, two pairs concepts essential PMapping – between ‘facts' ‘values' in being mapped ‘representation' ‘representativity Pmapping processes. Local not homogeneous; facts values distin...

Phosphoglucose isomerase (PGI) is a protein with multiple functions. To infer its structure changes and evolution in vertebrates, we cloned cDNAs encoding PGI genes from hagfish (Paramyxine yangi), gray mullet (Mugil cephalus), zebrafish (Danio rerio), toad (Bufo melanosticus), and snake (Boiga kraepelini). Only one PGI gene was cloned in each of hagfish, toad, and snake, but two PGI genes were...

Non-steroidal anti-inflammatory drugs (NSAIDs) exert their anti-inflammatory and anti-tumor effects by reducing prostaglandin (PG) production via the inhibition of cyclooxygenase (COX). However, the gastrointestinal, renal and cardiovascular side effects associated with the pharmacological inhibition of the COX enzymes have focused renewed attention onto other potential targets for NSAIDs. PGH2...

Retinoic acid (RA) exhibits anti-inflammatory, anti-tumor, and immuno-modulatory actions, and affects angiogenesis and thrombosis. Arachidonic acid (AA) metabolites are involved in all these processes. We explored the effect of RA on AA metabolism in human umbilical vein endothelial cells (HUVECs). 13-cis-RA increased the release of prostaglandin I(2) (PGI(2)), both spontaneous and thrombin-ind...

Loss of the modulatory role of the endothelium may be a critical initial factor in the development of diabetic vascular diseases. Exposure of human aortic endothelial cells (HAECs) to high glucose (30 or 44 mmol/l) for 7-10 days significantly increased the release of superoxide anion in response to the calcium ionophore A23187. Nitrate, a breakdown product of peroxynitrite (ONOO(-)), was substa...

BACKGROUND In addition to being a risk marker for cardiovascular disease, much recent data suggest that C-reactive protein (CRP) promotes atherogenesis. Decreased endothelial NO and prostacyclin (PGI2) contribute to a proatherogenic and prothrombotic state. We have shown that CRP decreases endothelial NO synthase expression and bioactivity in human aortic endothelial cells (HAECs). PGI2 is a po...

This study aimed to examine the 16 items of Personal Growth Initiative Scale-II (PGIS-II) psychometric traits among women holding corporate leadership positions in Indonesia. It used quantitative methods and was conducted on 181 various management positions. Confirmatory factor analysis (CFA) analyze PGIS-II instrument factorial validity comprising four dimensions determine structure suitabilit...

This paper examines the role of Intermediaries to support digital engagement, drawing from a study of Participatory Geographic Information Systems (PGIS). Working alongside the social enterprise Mapping for Change, four organisations and charities that developed Community Maps were asked to take part in semistructured interviews emphasising how PGIS could be designed to cater for broader inclus...

This study investigated the relationship among Iranian English teachers’ adversity quotient, personal growth initiative, and pedagogical success. The participants comprised 28 male and female English teachers and a total of 336 male and female EFL learners who attended the abovementioned teachers’ classes (12 for each teacher). Stoltz’ (1997) Adversity Response Profile (ARP) and Robitsc...