objective(s): gallium‐68 (ga‐68) is an ideal research and hospital‐based pet radioisotope. currently, the main form of ga‐68 radiopharmaceutical that is being synthesised in‐house is ga‐68 conjugated with dota based derivatives. the development of automated synthesis systems has increased the reliability, reproducibility and safety of radiopharmaceutical productions. here we report on our three...

Molecular imaging is the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in a living system. At present, positron emission tomography/computed tomography (PET/CT) is one the most rapidly growing areas of medical imaging, with many applications in the clinical management of patients with cancer. Although [(18)F]fluorodeoxyglucose (FDG...

Microglia, as cellular mediators of neuroinflammation, are implicated in the pathogenesis of a wide range of neurodegenerative diseases. Positron emission tomography (PET) imaging of microglia has matured over the last 20 years, through the development of radiopharmaceuticals targeting several molecular biomarkers of microglial activation and, among these, mainly the translocator protein-18 kDa...

until recently pet scanning has been available only at major universities or teaching hospitals possessing the necessary resources and expertise to operate a research pet facility. most dedicated pet centers cost several millions of dollars, and include a cyclotron, a radiochemistry laboratory to synthesize pet radiopharmaceuticals, a multicrystal dedicated pet camera, advanced computer facilit...

The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates ...

BACKGROUND Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different (18)F-radiopharmaceuticals for clinical characterization of Alzheimer's disease (AD) in different stages. However, distinct study cohorts and different quantification techniques allow only for an indirect comparison between the different tracers. Thus, the...

Positron emission tomography (PET) is a minimally invasive imaging procedure with a wide range of clinical and research applications. PET allows for the three-dimensional mapping of administered positron-emitting radiopharmaceuticals such as (18)F-fluorodeoxyglucose (for imaging glucose metabolism). PET enables the study of biologic function in both health and disease, in contrast to magnetic r...

G-protein-coupled brain receptors provide abundant targets for psychotropic drugs and have been widely explored by PET (positron-emission tomography) brain imaging. PET is a nuclear medicine technique consisting in injecting molecules that have been radiolabeled with positron-emitters such as fluoride-18 or carbon-11. When such radiotracers can be implemented in animal models or humans, they ar...

Positron emission tomography (PET) imaging has emerged as an important clinical tool for cancer management, and specifically targeted radiopharmaceuticals play critical roles on PET molecular imaging. Solid cancers have highly complex and heterogeneous microenvironment, this review focused on those microenvironmental factors such as hypoxia, proliferation and perfusion and, accordingly, a novel...