Objective(s): After decades of containment, pertussis disease, caused by Bordetella pertussis seems to be re-emerging and still remains a major cause of reported vaccine-preventable deaths worldwide. The current licensed whole-cell vaccines display reactogenicity while acellular vaccines are expensive and do not induce Th1-type immune responses that are required for optimum protection against t...

introduction: despite high level of vaccination against pertussis‚ whooping cough has re-emerged as a health threat, especially in infants. this could be related to expansion of bordetella pertussis with novel alleles for virulence factors including the pertussis toxin promoter, ptxp3. compared to ptxp1 strains‚ ptxp3 strains produce more pertussis toxin which results in immune suppression and ...

background pertussis is a highly communicable, vaccine-preventable respiratory disease; which may circulate even in populations with high vaccination coverage. although frequent, but it is often underestimated as a cause of prolonged cough illness in both children and adults. without boosting, the protection of the childhood vaccination would be minimal after 10 years. the need for adult booste...

OBJECTIVE Acellular pertussis vaccines were introduced with the promise of an improved safety profile compared with whole-cell vaccines. In 1997-1998, Canada adopted 1 combination acellular pertussis vaccine, having previously used 1 particular combination whole-cell pertussis vaccine. We hypothesized that the change would result in a decrease in hospitalization rates for seizures and reports o...

Pertussis is still endemic and the recently resurgence of the disease caused by Bordetella pertussis has been shown in many countries. The polymorphism of the virulence genes of B. pertussis and lack of any information about the allelic variation between the Iranian isolates promotes us to analysis of the genes encoded virulence factors including ptxS1, prn, fim3 and cya to understand the diffe...

Background: Despite primary vaccination, infants under six months run a risk of infection with pertussis. Objective: To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. Methods: All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The moth...

pertussis is still endemic and the recently resurgence of the disease caused by bordetella pertussis has been shown in many countries. the polymorphism of the virulence genes of b. pertussis and lack of any information about the allelic variation between the iranian isolates promotes us to analysis of the genes encoded virulence factors including ptxs1, prn, fim3 and cya to understand the diffe...

Pertussis or whooping cough is a highly infectious , vaccine preventable, acute respiratory tract disease. Historically, it is a disease of infants and children, but recent data reveals pertussis cases from patients of all ages and gender (1). Of particular importance are the cases of atypical, adolescent and adult pertussis, characterized by persistent cough. Both typical as well atypical pert...

In Japan, the morbidity rate for pertussis per 100,000 population was 147.6 in 1950 when whole cell pertussis vaccine was introduced but dropped to 0.2 in 1972 when routine immunization with a combined vaccine consisting of diphtheria toxoid, tetanus toxoid, and whole cell pertussis had been widely accepted. Thereafter, adverse reactions to the whole cell pertussis vaccine became a social probl...