Subtype-selective ligands are important tools for the pharmacological characterisation of neurotransmitter receptors. This is particularly the case for nicotinic acetylcholine receptors (nAChRs), given the heterogeneity of their subunit composition. In addition to agonists and antagonists that interact with the extracellular orthosteric nAChR binding site, a series of nAChR allosteric modulator...

Selective modulation of alpha7 nicotinic acetylcholine receptors (nAChRs) is thought to regulate processes impaired in schizophrenia, Alzheimer's disease, and other dementias. One approach to target alpha7 nAChRs is by positive allosteric modulation. Structurally diverse compounds, including PNU-120596, 4-naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta[c]quinoline-8-sulfonic acid amide (TQ...

An expeditious microwave-assisted synthesis of 4BP-TQS, its enantiomeric separation, and their functional evaluation is reported. Electrophysiological characterization in Xenopus oocytes revealed that activity exclusively resided in the (+)-enantiomer 1b (GAT107) and (-)-enantiomer 1a did not affect its activity when coapplied. X-ray crystallography studies revealed the absolute stereochemistry...

In this paper, an automatic method for Persian WordNet construction based on Prenceton WordNet 2.1 (PWN) is introduced. The proposed approach uses Persian and English corpora as well as a bilingual dictionary in order to make a mapping between PWN synsets and Persian words. Our method calculates a score for each candidate synset of a given Persian word and for each of its translation, it select...

Persian is one of the Indo-European languages which has borrowed its script from Arabic, a member of Semitic language family. Since Persian and Arabic scripts are so similar, problems arise when we want to process an electronic text. In this paper, some of the common problems faced experimentally in developing a corpus for Persian are discussed. The sources of the problems are the Persian scrip...

The Persian language is one of the dominant languages in the Middle East, so there are significant amount of Persian documents available on the Web. Due to the special and different nature of the Persian language compared to other languages like English, the design of information retrieval systems in Persian requires special considerations. However, there are relatively few studies on retrieval...

Persian is an Indo-European language written using Arabic script, and is an official language of Iran, Afghanistan, and Tajikistan. Transliteration of Persian to English—that is, the character-bycharacter mapping of a Persian word that is not readily available in a bilingual dictionary—is an unstudied problem. In this paper we make three novel contributions. First, we present performance compar...