Antimicrobial therapy remains to be the most important method of wound infection treatment. Systemically administered antimicrobials may not achieve therapeutic level in wound. On the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. Burn eschar is a protei...

A protocol for percutaneous absorption studies has been validated, based on the use of reconstructed human epidermis (RHE) and aqueous solutions of test substances. However, it is often the case that it is more-complex formulations of drugs or chemicals which will make contact with the skin surface. To investigate whether RHE and the reconstructed full-thickness skin model (FT-model) can be use...

Numerical simulation of tritium permeation from breeding zones to the coolant in the helium cooled pebble-bed blanket is performed in this paper. 2D and 3D convection–diffusion models are developed to account for the effects of purge stream convection. Incompressible transient Brinkman model with variable permeability is used in flow calculation, and transient diffusion and convection equations...

I would like to address two key issues related to the Perspectives on Ion Permeation . The first is the estimate of the size of the physical forces relevant for ion transport. Any good physical model of ion permeation requires the identification of the dominant forces. The second subject concerns a careful definition of the terms “mean field” and “mean field approximation.” Several articles in ...

I would like to address two key issues related to the Perspectives on Ion Permeation . The first is the estimate of the size of the physical forces relevant for ion transport. Any good physical model of ion permeation requires the identification of the dominant forces. The second subject concerns a careful definition of the terms “mean field” and “mean field approximation.” Several articles in ...

A gas permeation model (Coupling Model) has been developed which has the flexibility to be used for different membrane module configurations. The aim of this work is to predict the performance of a single stage gas separation process using membranes and provide a comprehensive description of process parameters like flow rates, composition, stage cut and stream pressure. The significant feature ...

the purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (ss) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. the influence of various permeation enhancers, such as dimethyl sul...

Borneol is a natural permeation enhancer that is effective in drugs used in traditional clinical practices as well as in modern scientific research. However, its molecular mechanism is not fully understood. In this study, a mixed coarse-grained model of stratum corneum (SC) lipid bilayer comprised of Ceramide-N-sphingosine (CER NS) 24:0, cholesterol (CHOL) and free fatty acids (FFA) 24:0 (2:2:1...

a gas permeation model (coupling model) has been developed which has the flexibility to be used for different membrane module configurations. the aim of this work is to predict the performance of a single stage gas separation process using membranes and provide a comprehensive description of process parameters like flow rates, composition, stage cut and stream pressure. the significant feature ...

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some comp...