نتایج جستجو برای: pepsinogen 2

تعداد نتایج: 2526241  

2014
Katsunori Iijima Tomoyuki Koike Yasuhiko Abe Tooru Shimosegawa

Measurement of the gastric acid secretion is useful for estimating the risk for various diseases in the upper gastro-intestinal tract; however, the procedure causes significant distress to the subjects. Pepsinogens I and II are secreted from the gastric fundic glands, and thus, the serum pepsinogen levels reflect the gastric functional statuses. The aim of this study is to establish appropriate...

Journal: :Gut 1999
F Kitahara K Kobayashi T Sato Y Kojima T Araki M A Fujino

BACKGROUND/AIMS The characteristics of pepsinogen screening for gastric cancer were investigated to establish a suitable cut off point for identifying gastric cancer, using endoscopic diagnosis as the yardstick. SUBJECTS/METHODS Serum pepsinogen concentrations were measured in 5113 subjects who were also screened for gastric cancer by endoscopy. The cut off point for pepsinogen was determined...

Journal: :Journal of clinical pathology 1984
J Défize G Pals R R Frants B D Westerveld S G Meuwissen A W Erkisson

De novo synthesis of pepsinogen was shown in isolated rabbit and human gastric glands after incubation of the glands in a 14C labelled amino acid enriched minimum Eagles medium. At regular intervals, glands and medium were separated and analysed by polyacrylamide gel electrophoresis. Newly synthesised pepsinogen was shown by autoradiography. Incorporation of 14C labelled amino acids was detecte...

Journal: :Gut 1992
R A Veenendaal I Biemond A S Peña W van Duijn J Kreuning C B Lamers

In a healthy population pepsinogen A and pepsinogen C increase with advancing age. As pepsinogen A and C are raised in chronic superficial gastritis which is caused by H pylori infection, we investigated whether H pylori is responsible for the age related increase of pepsinogen A and C. In H pylori positive blood transfusion donors serum pepsinogen A (mean (SD) 73 (35) micrograms/ml v 52 (19) m...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008
Kimihiko Yanaoka Masashi Oka Chizu Mukoubayashi Noriko Yoshimura Shotaro Enomoto Mikitaka Iguchi Hirohito Magari Hirotoshi Utsunomiya Hideyuki Tamai Kenji Arii Hiroshi Ohata Mitsuhiro Fujishiro Tatsuya Takeshita Osamu Mohara Masao Ichinose

BACKGROUND Gastric cancer screening using the pepsinogen filter test is receiving wide recognition in Japan owing to convenience, freedom from discomfort or risk, efficiency, and economy. Because the long-term outcomes of cancer development in extensive atrophic gastritis detected by pepsinogen test are unclear, test-positive and test-negative subjects were investigated in a longitudinal cohort...

Journal: :Gut 1995
A I Lanas J Nerín F Esteva R Sáinz

The effects of aspirin and ibuprofen on pepsinogen secretion were studied in isolated human peptic cells prepared from endoscopically obtained biopsy specimens after collagenase digestion, mechanical disruption, and percoll gradient centrifugation. Pharmacological concentrations of aspirin and ibuprofen (10(-8)-10(-4) M), potentiated histamine (10(-6)-10(-4)M) and forskolin (10(-5)M) stimulated...

Journal: :Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie 1989
I Biemond J B Jansen L F Crobach J Kreuning C B Lamers

We describe the development of radioimmunoassays to measure both human pepsinogen A and pepsinogen C concentrations in serum. The antibodies were raised in goats by immunization with purified pepsinogen A or C. The affinity constants of the respective antibodies were 20.10(10) l/mol and 7.10(10) l/mol. Pepsinogens A and C were labeled with Na 125I by the chloramine T method. The binding between...

Journal: :The Journal of biological chemistry 1981
K Sogawa Y Ichihara K Takahashi Y Fujii-Kuriyama M Muramatsu

Poly(A)-containing RNA was isolated from total RNA of swine gastric mucosa by oligo(dT)-cellulose chromatography, and was translated in a wheat germ cell-free system. Analysis of the translation products by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that pepsinogen was a major translation product and was synthesized as two different molecular forms with apparent molecula...

Journal: :Helicobacter 2011
Hiroshi Kishikawa Jiro Nishida Hitoshi Ichikawa Shogo Kaida Sakiko Takarabe Takashi Matsukubo Soichiro Miura Tetsuo Morishita Toshifumi Hibi

BACKGROUND The clinical significance of Helicobacter pylori antibody titer has been controversial, and the association between the extent of gastric atrophy or acid secretion and H. pylori antibody concentration has not been elucidated. MATERIALS AND METHODS Serum pepsinogen, H. pylori antibody concentration, and fasting gastric pH (as an indicator of acid secretion) were measured in 231 pati...

Journal: :Gut 1995
R J Schlemper S D van der Werf J P Vandenbroucke I Biemond C B Lamers

Serological markers of gastritis, like pepsinogen A, pepsinogen C, gastrin, and Helicobacter pylori antibodies, can be used to explore the state of the gastric mucosa in populations with contrasting cancer risks. A decreasing pepsinogen A:C ratio and an increasing serum gastrin are known to reflect an increasing severity of atrophic corpus gastritis, which is a precursor of gastric cancer. In 7...

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