High pressure and anaesthetic agents are mutual antagonists in intact animals, but antagonism is not observed in isolated nerve cells. In order to test the hypothesis that a neural network might display pressure-anaesthetic antagonism not found in simpler systems, we have examined the effects of pentobarbitone at normal pressure and at 10.1 MPa helium pressure on the rhythmic activity of medull...

The aim of the present study was to investigate the sleep promoting effect of BR-16A, a polyherbal formulation along with GABAergic drugs. Pentobarbitone-induced hypnosis test was used as an animal model to explore its role in sleep. Pentobarbitone produces quick the sleep latency (onset) and prolongation of total sleep time (duration). Seep latency and total sleep time were used as parameters ...

The aim of the present study was to investigate the sleep promoting effect of BR-16A, a polyherbal formulation along with GABAergic drugs. Pentobarbitone-induced hypnosis test was used as an animal model to explore its role in sleep. Pentobarbitone produces quick the sleep latency (onset) and prolongation of total sleep time (duration). Seep latency and total sleep time were used as parameters ...

objectives: the aim of present study was to evaluate some effects of crinum zeylanicum (c. zeylanicum) on central nervous system. materials and methods: c. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using irwin test, pentobarbitone-induced sleep test, spontaneous motor activ...

Sir,—Thank you for the opportunity of replying to the letter from Drs Bradshaw and Maddison. We can assume only that these workers have been unable to confirm our observations because of some fundamental difference in technique. The difference is not immediately apparent from the information provided in their letter, but several possibilities exist. First, our patients, who were not premedicate...

1. Interactions were investigated between loreclezole, chlormethiazole and pentobarbitone as potentiators of depolarization responses mediated by gamma-aminobutyric acid(A) (GABA(A)) receptors on afferent nerve terminals in the rat cuneate nucleus in vitro. These drugs were also compared as modulators of [3H]-flunitrazepam (FNZ) binding to synaptic membranes prepared from rat whole brain homoge...