PEGylated polypropyleneimine (PPI) dendritic scaffold was used for the delivery of an anti-leukemic drug, Imatinib. The current study evolves and emerges the use PEGylated PPI dendritic scaffold for the delivery of this drug. In this Imatinib was synthesized and loaded with PEGylated PPI dendritic scaffold. Parameters such as FT-IR, NMR, SEM, drug release, DSC and hemolytictoxicity are required...

PEGylated polypropyleneimine (PPI) dendritic scaffold was used for the delivery of an anti-leukemic drug, Imatinib. The current study evolves and emerges the use PEGylated PPI dendritic scaffold for the delivery of this drug. In this Imatinib was synthesized and loaded with PEGylated PPI dendritic scaffold. Parameters such as FT-IR, NMR, SEM, drug release, DSC and hemolytictoxicity are required...

background after treatment cessation, a high prevalence of relapse was reported in chronic hepatitis b (chb) patients in china, especially in nucleot(s)ide analogues (nucs)-experienced patients. re-treatment for these patients remains unsolved. objectives this study aims to evaluate the efficacy of pegylated interferon in hbeag positive patients with exposure to antiviral therapy. patients and ...

Background: DAB389IL-2 is considered a fusion immunotoxin and it is used for the CTCL therapy. DAB389IL-2 includes of two distinct portions; the catalytic domain of diphtheria toxin and IL-2. DAB389IL-2 duo to the presence of a free cysteine residue (Cys 513 in IL-2 part) is prone to unwanted intramolecular and intermolecular disulfide bonds formation and aggregation problems. Aggregation is co...

We propose a knowledge-based approach to the task of determining the topology of mul-tilayer perceptrons (MLPs). The idea consists in integrating well-founded and empirically proven connguration techniques into a knowledge-based system. A preliminary study showed that the use of these techniques depends primarily on the amount of prior domain knowledge available: connguration techniques can be ...

The growing memory wall1 makes speedups increasingly difficult to achieve on applications that exhibit difficult-topredict memory access patterns. The problem is that although modern processors provide multiple high-bandwidth execution units, applications that experience frequent cache misses are only executed with high IPC in the periods between misses. As main memory latencies increase from 2...

OBJECTIVE Recognizing and managing of admitted patients in intensive care unit (ICU) with high risk of mortality is important for maximizing the patient's outcomes and minimizing the costs. This study is based on linear and nonlinear analysis of heart rate variability (HRV) to design a classifier for mortality prediction of cardio vascular patients admitted to ICU. METHODS In this study we ev...

BACKGROUND Liver cirrhosis (LC) is the final stage of most of chronic liver diseases and is almost caused by chronic hepatitis B (CHB) in China. Liver biopsy is the reference method for the evaluation of liver cirrhosis. However, it is an invasive procedure with inherent risk. The aim of this study was to construct a new classifier based on the routine clinical markers for the prediction of HBV...