Standardized poly(ethylene glycol)-modified (PEGylated) liposomes, which have been widely used in research as well as in pre-clinical and clinical studies, are typically constructed using PEG with a molecular weight of 2000 Da (PEG(2000)). Targeting ligands are also generally conjugated using various functionalized PEG(2000)). However, although standardized protocols have routinely used PEG(200...

Abstract Palm oil polyol-based foams have inflexible and brittle properties. polyols a lower molecular weight. Polyols with high weight primary OH group, such as polyethylene glycol (PEG)-400, can provide the flexible properties of polyurethane foam. This study aimed to examine optimum concentration PEG-400, which produce foam made from palm best characteristics based on mechanical compared pol...

We have found that 1-alkyl-3-methylimidazolium chloride ionic liquids (ILs) can form immiscible liquid mixtures with some polyethylene glycols (PEGs). Binary mixtures of 1-ethyl-3-methylimidazolium chloride with PEG of molecular weight 1500, 2000, or 3400 g mol(-1), or of 1-butyl-3-methylimidazolium chloride with PEG of molecular weight 2000 or 3400 g mol(-1), have been found to give rise to en...

Structurally well-defined ABA triblock copolymers with low molecular weight linear polyethylenimine (PEI) as A block and poly(ethylene glycol) (PEG) as B block have been prepared and used for gene delivery. PEI–PEG–PEI 2100–3400–2100 can effectively condense DNA, giving small-sized polyplexes (b100 nm) with reduced zeta-potentials (b10 mV). Initial experiments show that these polyplexes have a ...

Insight in the osmotic behavior of degrading hydrogels is of great importance in the design of biodegradable hydrogels for biomedical applications. This study compares the degradation behavior of PEG-HEMA (hydroxyethylmethacrylated polyethylene glycol) and dex-HEMA (hydroxyethylmethacrylated dextran) hydrogels. The degradation of PEG-HEMA gels takes several months to over a year, while that of ...

Gene silencing by RNA interference (RNAi) is a promising approach for gene therapy. However, up to today, it is still a major challenge to find safe and efficient non-viral vectors. Previously, we reported PEI-Bu, a small molecular weight PEI derivative, as an efficient non-viral carrier. However, like many PEI-based polymers, PEI-Bu was too toxic. In order to reduce cytotoxicity while maintain...

Colon-specific delivery of metabolically labile molecules, such as proteins and peptides, is of particular interest in pharmaceutical research. Among the factors that may influence the permeability of drug molecules across colonic mucosa are their molecular weight and geometry. The purpose of this study was to evaluate the influence of molecular geometry on in vitro permeability across rabbit d...

Poly(ethlene terephthalate) (PET) used in artificial heart valve sewing rings were treated by argon plasma discharge and grafted by different molecular water-soluble polymer—polyethylene glycols (PEG). The surface properties of the plasma treated and grafted films were determined by contact angle measurement, X-ray photoelectron spectroscopy (XPS), and attenuated total reflection Fourier transf...

The phase behavior of poly(ethylene glycol) grafted liposomes (PEG-liposomes) was investigated by differential scanning calorimetry (DSC), dynamic light scattering (DLS) and cryo-transmission electron microscopy (cryo-TEM). PEG-liposomes were prepared from mixtures of dipalmitoyl phosphatidylcholine (DPPC) and distearoyl phosphatidylethanolamine with a covalently attached PEG molecular weight o...