In order to develop the polymer materials having temperature-sensitive and high biological safety, Eudragit RS-PO and polyethylene glycol 400 (PEG 400) blend polymers (EPG) were prepared. The EPGs that have the glass transition temperature (Tg) at around the body temperature were prepared by the addition of 5--13% PEG 400 to Eudragit RS. As glassy polymers are not in thermodynamic equilibrium b...

Porcine corneas were frozen with Me2SO, glycerol, 1,2-propanediol and PEG-400. The effects of the range of concentrations (5% and 10%) and temperature regimen (1oC/min and 5oC/min) were investigated. The integrity of corneal endothelial cells was evaluated by scanning electron microscopy and trypan blue staining. The presence of 5–10% PEG-400 in the protective medium was the most effective in m...

Integration of liposomes in polymer matrix is a new concept of controlled drug delivery system. Those kind of materials allow to control dosage of applied drug and time of its release. Certain types of liposomes are unstable, so they require structural support. The main aim of the paper is to investigate how polymers influence aggregation of liposomes. Two different polymers were used for this ...

The effect of a polymer, polyethylene glycol with a molecular weight of 400 (PEG-400), on the dynamics of solvent and rotational relaxation have been investigated in [bmim][BF4]/TX100/cyclohexane microemulsions using steady state and time resolved fluorescence spectroscopy as a tool and coumarin 480 (C-480) as a fluorescence probe. The size of the microemulsions increases with addition of PEG-4...

An alternative green method was developed for the synthesis of thio- and selenoflavones by ring closure 2-chlorophenyl ethynyl ketone with NaHY (Y = S, Se). These nucleophilic chalcogen species were generated in situ using NaBH4 to reduce elemental presence polyethylene glycol-400 (PEG-400). The efficiency this reaction is strongly dependent on PEG-400 solvent, acting like a crown ether, comple...

The adsorption equilibrium and kinetics of polyethylene glycol (PEG) in three aqueous systems were examined in this study. Langmuir isotherm was used to satisfactorily predict the adsorption capacity of PEG on activated carbon F-400 and applied to the investigation of adsorption kinetics. The surface diffusion, pore diffusion, and branched pore kinetics models successfully described the adsorpt...

Vitamin E D-alpha-tocopheryl polyethylene glycol succinate (TPGS) and polyethylene glycol are common excipients used in both preclinical and commercial formulations. In this paper, the phase diagrams of TPGS and polyethylene glycol 400 (PEG 400) in the presence of either water or ethanol were constructed. The effect of water and ethanol on the cloud point temperature of TPGS-PEG 400 mixtures wa...

Paracetamol sirup memiliki sifat yang mudah terdispersi dalam air sehingga untuk menjaga agar paracetamol tetap stabil bentuk sediaan diperlukan formulasi tepat kestabilan sirup. Sirup adalah cair nyaman diberikan kepada pasien, dan praktis pemberian obat terhadap anak-anak, karena mempunyai rasa enak mengenyahkan keenganan beberapa anak minum obat. Tujuan dari penelitian ini menetapkan struktu...