Pedigree graphs, which represent family relationships, are often constructed by collecting data from genealogical records to determine which pairs of people are parent and child. This process is expensive, and small mistakes in data collection–for example, one missing parent-child relationship–can cause large differences in the pedigree graphs created. In this paper, we introduce a simple pedig...

AIMS To characterise the inheritance of ptosis in one particular pedigree. METHODS The pedigree was analysed clinically and genetically to assess the mode of inheritance and to ascribe a gene locus for the condition. RESULTS Affected members of the pedigree have bilateral symmetrical congenital isolated ptosis, a condition which is linked to genetic markers on the X chromosome in this famil...

BACKGROUND The kinship2 package is restructured from the previous kinship package. Existing features are now enhanced and new features added for handling pedigree objects. METHODS Pedigree plotting features have been updated to display features on complex pedigrees while adhering to pedigree plotting standards. Kinship matrices can now be calculated for the X chromosome. Other methods have be...

The standard method of studying inherited disease is to observe its pattern of distribution in families, that is, its pattern in a pedigree. For clinical studies focused on inherited disease, a pedigree diagram is a valuable visual tool for the display of inheritance patterns. We describe the creation of a web-based pedigree display module for Trial/DB, a Web accessible database developed at th...

in general, both common illnesses and rare diseases can develop in people and their relatives in families. therefore, taking family history is an effective screening tool to detect such diseases and patients should be aware of its importance in families’ health with updating information in regular visiting. for more information on identifying the genetic pattern of diseases, in this article, we...

In this paper, we study a problem of inferring blood relationships which satisfy a given matrix of genetic distances between all pairs of n nodes. Blood relationships are represented by our proposed graph class, which is called a pedigree graph. A pedigree graph is a directed acyclic graph in which the maximum indegree is at most two. We show that the number of pedigree graphs which satisfy the...

Studying population isolates with large, complex pedigrees has many advantages for discovering genetic susceptibility loci; however, statistical analyses can be computationally challenging. Allelic association tests need to be corrected for relatedness among study participants, and linkage analyses require subdividing and simplifying the pedigree structures. We have extended GenomeSIMLA to simu...

OBJECTIVE To investigate the completeness of pedigree and of number of pedigree analysis to know the acceptable familial history in Korean women with ovarian cancer. METHODS Interview was conducted in 50 ovarian cancer patients for obtaining familial history three times over the 6 weeks. The completeness of pedigree is estimated in terms of familial history of disease (cancer), health status ...