BACKGROUND The Circle of Willis (CoW) is an important collateral pathway of the cerebral blood flow. An experimental study of the cerebral blood flow (CBF) distribution in different anatomical variations may help to a better understanding of the collateral mechanism of the CoW. METHODS An in-vitro test rig was developed to simulate the physiological cerebral blood flow in the CoW. Ten anatomi...

Lipids are main fuels for cellular energy and mitochondria their major oxidation site. Yet unknown is to what extent the fuel role of lipids is influenced by their uncoupling effects, and how this affects mitochondrial energetics, redox balance and the emission of reactive oxygen species (ROS). Employing a combined experimental-computational approach, we comparatively analyze β-oxidation of pal...

BACKGROUND AND PURPOSE The purpose of the present study was to assess whether the direction of flow via the circle of Willis and the ophthalmic artery (OphA) changed over time in patients with a symptomatic occlusion of the internal carotid artery (ICA) who did not experience recurrent cerebral ischemic symptoms. METHODS Sixty-two patients with a symptomatic ICA occlusion were investigated wi...

Spontaneous pure acute bilateral subdural haematoma (ASDH) without intraparenchymal or subarachnoid haemorrhage caused by a ruptured cerebral aneurysm is extremely rare. It can follow rupture of different aneurysms specially located in anterior incisural space; the most frequently encountered location is the PcoA aneurysms as demonstrated in the present case. We present a case report of a PcoA ...

BACKGROUND AND PURPOSE In some people the blood supply to the posterior cerebral artery occurs partly or even exclusively via the carotid system. This anatomic configuration may influence the risk of occipital lobe infarction. We studied the presence and direction of flow in the posterior communicating artery (PCoA) in patients with an occipital lobe infarct and in healthy controls. METHODS F...

INTRODUCTION The circle of Willis is thought to play a key role in development of collateral flow in patients with internal carotid artery stenosis (ICAS). AIM To assess flow in the circle of Willis in patients with recent ischemic stroke (IS). MATERIAL AND METHODS The study included 371 patients, 102 symptomatic with severe ICAS and recent IS (within the last 3 months) (group I) and 269 as...

A pure posteriorly posterior communicating artery (PCoA) aneurysm represents a surgical challenge. This is mainly when there need for good exposure of the aneurysmal neck, sac, PCoA, and anterior choroidal arteries. Ruptured directed PCoA imposes significantly extra challenge as surgeon undergoes dissection through tight brain. Even with measures commonly used to attain brain relaxation like lu...

This study aims to identify and yield a better understanding of the origin of the posterior communicating artery, its perforating branches and the relations in the vicinity of that artery. In 30 brains filled with a mixture of latex through the internal carotid and basilar arteries the posterior communicating artery originated from the posterior aspect of the C4 part of the internal carotid art...

BACKGROUND Aneurysms of the posterior cerebral artery (PCA) are rare and often associated with anterior circulation aneurysms. The lateral supraorbital approach allows for a very fast and safe approach to the ipsilateral lesions Circle of Willis. A technical note on the successful clip occlusion of two aneurysms in the anterior and posterior Circle of Willis via this less invasive approach has ...