The products of the mammalian Pbx and Drosophila exd genes are able to interact with Hox proteins specifically and to increase their DNA binding affinity and selectivity. In the accompanying paper we show that Pbx proteins exist as stable heterodimers with a novel homeodomain protein, Prep1. Here we show that Prep1-Pbx interaction presents novel structural features: it is independent of DNA bin...

Pbx cofactors are implicated to play important roles in modulating the DNA-binding properties of heterologous homeodomain proteins, including class I Hox proteins. To assess how Pbx proteins influence Hox DNA-binding specificity, we used a binding-site selection approach to determine high-affinity target sites recognized by various Pbx-Hox homeoprotein complexes. Pbx-Hox heterodimers preferred ...

Current experiments show that the TATB-based polymer bonded explosives (PBX) will experience irreversible growth when suffered temperature cycling load. Although some studies have already been done on this, cause of is still confusing, and mechanism not clear. In order to study PBX under load, an thermal-viscoelastic model established, Based Burgers which considering influence different tempera...

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Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue m...

The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they are also dysregulated in a wide range of solid and haematological malignancies and have a predominantly pro-oncogenic function. A key mode of transcriptional regulation by HOX and PBX protei...

PURPOSE To define the impact of discordant Gleason sum (GS) between prostate biopsy (Pbx) tissue and radical prostatectomy (RP) specimen among men initially diagnosed with Gleason 6 or 7 prostate adenocarcinoma. MATERIALS AND METHODS We evaluated patients diagnosed with GS 6 or 7 and treated primarily with RP. We defined the frequency of GS discordance between Pbx and RP pathology reports. We...

A PBX, or private branch exchange, is a private telephone network used within an enterprise. The PBX telephone migration problem arises when an enterprise acquires a new PBX to replace an existing one. Phone numbers need to migrate from the old system to the new system over a time horizon. A penalty, assigned to the each pair of phones, is incurred if the pair is migrated in different time peri...

Craig Pollard, head of project management at Siemens Communications examines the increasing threat of telephony fraud and highlights the vulnerabilities to IT managers. a 2005 Elsevier Ltd. All rights reserved. It is probably little surprise that telephony fraud has become big business. However, with the International Forum of Irregular Network Access estimating that the total cost of telephony...

OBJECTIVES There is little data about the clinical value of core length for prostate biopsy (PBx). We investigated the clinical values of various clinicopathological biopsy-related parameters, including core length, in the contemporary multi-core PBx. PATIENTS AND METHODS Medical records of 5,243 consecutive patients who received PBx at our institution were reviewed. Among them, 3,479 patient...