BACKGROUND/AIM Pancytopenia is caused by acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), aplastic anemia (AA), or by non-hematological diseases. Because Wilms' tumor-1 (WT1) is overexpressed in patients with AML and MDS, its expression level may be helpful for diagnosing these hematological malignancies. PATIENTS AND METHODS We retrospectively investigated the WT1 transcripts in...

Toxic metals are bioaccumulated by insectivorous mammals but few studies (none from Britain) have quantified residues in bats. We measured renal mercury (Hg), lead (Pb) and cadmium (Cd) concentrations in bats from south-west England to determine how they varied with species, sex, age, and over time, and if they were likely to cause adverse effects. Residues were generally highest in whiskered b...

Occupational and environmental exposures to lead (Pb), one of the toxic metal pollutants, is of global concern. Health risks are increasingly associated with environmental exposures to Pb emissions from, for example, the widespread use of leaded gasoline in developing countries. Exposure occurs mainly through the respiratory and gastrointestinal systems, and the ingested and absorbed Pb is stor...

BACKGROUND There is growing pressure for clinicians to prescribe chelation therapy at only slightly elevated blood lead levels. However, very few studies have evaluated whether chelation improves cognitive outcomes in Pb-exposed children, or whether these agents have adverse effects that may affect brain development in the absence of Pb exposure. OBJECTIVES The present study was designed to a...

The objective of this manuscript is to provide a description of the International Commission for Radiation Protection (ICRP) model and a comparison to other models (the integrated exposure uptake biokinetic [IEUBK] and O'Flaherty models), including the software used with the models, and a comparison of the model predictions for selected situations. The ICRP biokinetic model for Pb is a multicom...

The present study was undertaken to investigate whether treatment with vitamin E (VE) protects against intoxication induced by lead (Pb) exposure in Oreochromis niloticus. Fish were exposed for 60 days to a 10 mg Pb / Kg diet. The oxidative stress affected by Pb in fish was treated by antioxidant (VE) supplementation. Fish were assigned to four dietary groups. The diets differed in their consti...

Recent studies found folic acid is associated with lower blood lead (Pb) levels, and folate deficient children are more susceptible to the negative cognitive effects of Pb. This study evaluated the protective effects of folate supplementation against Pb exposure in rat pups and the mechanisms of protection. A total of 72 rats were used. Thirty were administered Pb only; 30, Pb and folic acid at...

Background The topic of food safety has become a major public health issue worldwide. Over recent decades, the growing concern for food safety has brought about greater research regarding the risks associated with the consumption of produce that has been contaminated by pesticides, heavy metals and/or toxins. Objective The study was conducted to determine the concentration of Pb in the muscle...

Inorganic Pb acetate is a pro-oxidant, and peroxidation damage to cellular membrane lipids, leading to membrane fragility and permeability, is a likely consequence of Pb poisoning. In addition to the systemic peroxidation that occurs in vivo, Pb-contaminated feedstuffs can contribute preformed peroxides. Treatments with dietary Pb that have been shown to increase tissue peroxide levels in anima...

We tested the hypothesis that pyridostigmine bromide (PB) intake and/or low-level sarin exposure, suggested by some as causes of the symptoms experienced by Persian Gulf War veterans, induce neurobehavioral dysfunction that outlasts their effects on cholinesterase. Adult male Sprague-Dawley rats were treated during 3 weeks with s.c. saline, PB in drinking water (80 mg/l), sarin (62.5 microg/kg;...