The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an essential signaling platform, serving as a convergence point for integrin and growth-factor signaling and regulating cell adhesion, spreading, and migration. We report a 1.6-A crystal structure of the ILK ankyrin repeat domain bound to the PINCH1 LIM1 domain, revealing the molecular basis of ILK-PINCH inter...

as the form and appearance of a literature work inevitably affect thestructure and shape ofthatwork, theyplay animportant role in its permanence.in this study, factors and elementsaffecting the cohesion, coherence, form and structure of allegories and debates in parvin'scollection were analyzed using a systematic method. the results of the study can becategorizedin four groups. first, in p...

Abdolrazagh Hashemi-Shahraki, Parvin Heidarieh, Samira Azarpira, Hasan Shojaei, Mohammad Hashemzadeh and Enrico Tortoli Author affiliation: Pasteur Institute of Iran, Tehran, Iran (A. Hashemi-Shahraki, S. Azarpira, M. Hashemzadeh); Alborz University of Medical Sciences, Karaj, Iran (P. Heidarieh); Isfahan University of Medical Sciences, Isfahan, Iran (H. Shojaei); and San Raffaele Scientific In...

Parvin-e E`tesami, the daughter of Yousef E`tesami, was one of the eminent poets of the constitutional period. Her father, E`tesam al-Molk was a remarkable intellectual. He was one of the very first translators and one of the writers whose work started Romanticism in Iran in the last years of Qajar dynasty. He translated pieces from a vast range of topics and, thus, he had an undeniable role in...

Afsaneh Koochek ([email protected]) Parvin Mirmiran ([email protected]) Kristina Sundquist ([email protected]) Firoozeh Hosseini ([email protected]) Tohid Azizi ([email protected]) Ali S Moeini ([email protected]) Sven-Erik Johansson ([email protected]) Brita Karlström ([email protected]) Fereidoun Azizi ([email protected]) Jan Sundquist (Jan.Sundqu...

The focal adhesion (FA) protein α-Parvin (αPv) has been shown to regulate integrin signalingand integrin-actin linkage. Here we report that the conditional deletion of the αPv gene inkeratinocytes leads to impaired hair follicle (HF) morphogenesis, epidermal hyperplasia andmicro-blistering. Expression of integrin α6 was reduced on αPv-deficient keratinocytes,leading to defects i...

E ndothelial cells (ECs) covering the inner surface of blood and lymphatic vessels 1 create an interface between circulating blood and lymph and the surrounding tissue. Hence, ECs are crucially involved in maintaining the integrity of all tissues. In addition, the formation of new vessel, eg, during wound healing processes, is determined by ECs. 2 Thus, the maintenance of a structural and funct...

Samples with Increased Urea, J. Keith Pinckard, Janet Zahn, Lori Ashby, Curtis A. Parvin, and Mitchell G. Scott ( Washington University School of Medicine, Division of Laboratory Medicine, Box 8118, 660 South Euclid Ave., St. Louis, MO 63110; 2 Barnes-Jewish Hospital, Department of Laboratories, One Barnes-Jewish Hospital Plaza, St. Louis, MO 63110; * author for correspondence: fax 314362-1461,...