The membrane-bound EssB is an integral and essential component of the bacterial type VII secretion system that can contribute to pathogenicity. The architecture of Geobacillus thermodenitrificans EssB has been investigated by combining crystallographic and EPR spectroscopic methods. The protein forms a dimer that straddles the cytoplasmic membrane. A helical fold is observed for the C-terminal ...

Secretins form megadalton bacterial-membrane channels in at least four sophisticated multiprotein systems that are crucial for translocation of proteins and assembled fibers across the outer membrane of many species of bacteria. Secretin subunits contain multiple domains, which interact with numerous other proteins, including pilotins, secretion-system partner proteins, and exoproteins. Our und...

Initially identified in pathogenic Gram-negative bacteria, the two-partner secretion (TPS) pathway, also known as Type Vb secretion, mediates the translocation across the outer membrane of large effector proteins involved in interactions between these pathogens and their hosts. More recently, distinct TPS systems have been shown to secrete toxic effector domains that participate in inter-bacter...

Précis This debate article highlights the challenges of health situation in Iran and some influencing or relevant factors such as health sector, welfare system and social protection, social exclusion and civil society from the viewpoint of an international partner. Some advanced experiences in Iranian health system and the manner of system for international cooperation have also been discussed.

veterans with post traumatic stress disorder (ptsd) suffer from distressing and disabling symptoms. many studies have shown that ptsd symptoms can negatively influence quality of life of their partners. this study was designed to assess general health, marital satisfaction and self-esteem levels of partners of iranian veterans with ptsd. we performed a case-control study. cases were comprised o...

The Gram-negative methanotroph Methylococcus capsulatus (Bath) was recently demonstrated to abrogate inflammation in a murine model of inflammatory bowel disease, suggesting interactions with cells involved in maintaining mucosal homeostasis and emphasizing the importance of understanding the many properties of M. capsulatus. Secreted proteins determine how bacteria may interact with their envi...

Firms no longer compete as autonomous entities and prefer to join in a supply chain alliance to take advantage of highly competitive business situation. Supply chain coordination has a great impact on strategic partnering and success of a firm in competitive business environment. In this paper, we propose a system dynamics simulation model for strategic partner selection in supply chain. Our mo...