neurodegenerative disorders such as huntingtons disease, alzheimers disease, parkinsons disease, amyotrophic lateral sclerosis, spinal muscular atrophy, friedreichs ataxia, and others are multi-factorial illnesses in which many pathways (still poorly understood) act serially and in parallel to give a determined pathologic phenotype. thus, presently there are no effective cures for these disease...

BACKGROUND The 39 item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient reported rating scale in Parkinson's disease. However, several fundamental measurement assumptions necessary for confident use and interpretation of the eight PDQ-39 scales have not been fully addressed. METHODS Postal survey PDQ-39 data from 202 people with Parkinson's disease (54% men; mean age...

background: health related quality of life is an important outcome measure in studies involving patients with chronic neurological conditions. disease specific patient reported outcome measures (proms) are increasingly used as primary end points in clinical trials. the most widely used disease specific prom is the 39 item parkinson's disease questionnaire (pdq-39). the aim of this study was to ...

PURPOSE To evaluate the reliability and validity of the Korean version of the 39-item Parkinson's disease questionnaire (PDQ-39). METHODS Cross-cultural adaptation was performed according to the international guidelines: forward and backward translation, focus group meeting, and a field test. With Korean consensus translation produced, validation was assessed by evaluating reliability and val...