Mutations in the the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson disease and some cases of sporadic Parkinson disease. Here we found that LRRK2 kinase activity was regulated by GTP via the intrinsic GTPase Roc domain, and alterations of LRRK2 protein that reduced kinase activity of mutant LRRK2 correspondingly reduced neuronal toxicity. These data elucidate the ...

whole body vibration (wbv) is a contemporary treatment modality that holds promise as an exercise training method in health–compromised individuals. a growing number of studies on individuals with parkinson disease are examining whether wbv improves balance and functional mobility. however, interpreting wbv studies is challenging since there is variability in the manner in which wbv interventio...

A Doença de Parkinson (DP) tem como fisiopatologia a disfunção neurotransmissores, principalmente perda progressiva dos neurônios dopaminérgicos da porção compacta substância negra, que exerce importante função no controle motor do indivíduo. O projeto extensão “Assistência Fisioterapêutica em Grupo para Indivíduos com Parkinson” (AGruPar) propósito realizar atendimentos grupo indivíduos diagno...

The objective of this study was to determine whether hypothyroidism is more common in Parkinson patients than in a control group without Parkinson, as suggested in the past. We performed a retrospective file review of all admissions to the geriatric ward during a 1-year period. Concentrations of thyroid stimulating hormone (TSH) and thyroxine (T4) from 92 Parkinson patients were compared with t...

BACKGROUND Most prognostic studies on Parkinson disease have been hospital based or have applied register-based case-finding methods. Potential under-representation of mild cases may have given biased results. OBJECTIVE To evaluate whether Parkinson disease is associated with an increased risk of dementia and death. DESIGN Population-based cohort study. Parkinson disease and dementia were a...

The effects of the inflammatory mediators involved in systemic lupus erythematous (SLE) on subsequent Parkinson disease have been reported, but no relevant studies have focused on the association between the 2 diseases. This nationwide population-based study evaluated the risk of Parkinson disease in patients with SLE.We identified 12,817 patients in the Taiwan National Health Insurance databas...

PURPOSE To determine whether the proton spectra from patients with clinically diagnosed Parkinson disease differ from the spectra of age-matched healthy subjects with respect to the major cerebral metabolite resonances as well as lactate. METHODS Fourteen patients with Parkinson disease (38 to 81 years of age) and 13 healthy control subjects (37 to 81 years of age) were studied using image-gu...

INTRODUCTION This epidemiological survey estimates the hospitalization burden related to Parkinson´s Disease in Spain. METHODS This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalizations of patients with Parkinson´s disease that were reported from 1997-2...

Background Parkinson disease is the second most common neurodegenerative disease and the proportion of people suffering from parkinsonism and Parkinson disease is expected to increase as populations age. Few studies investigated the incidence of parkinsonism and Parkinson disease in the general population, and most of these were based on clinical data only. Objective To estimate the incidence o...