BACKGROUND The NEI VFQ-25 has undergone psychometric evaluation in patients with varying ocular conditions and the general population. However, important limitations which may affect the interpretation of clinical trial results have been previously identified, such as concerns with reliability and validity. The purpose of this study was to evaluate the National Eye Institute Visual Functioning ...

PURPOSE To test the assumption that the National Eye Institute Visual Function Questionnaire (NEI VFQ) measures visual functioning, assess the validity of its subscales, and, if flawed, revise the questionnaire and derive a shortened version with sound psychometric properties. SETTING Flinders Medical Centre, Adelaide, Australia. METHODS Patients from the cataract surgery waiting list self-...

As a nonspecific physical stimulation, the effect of acupuncture on diseases is produced by motivating the inherent regulatory system in the body, having the characteristics of whole regulation, dual directional regulation, etc. Modern scientific researches show that body's inherent regulatory system is neuro-endocrine-immune (NEI) network. Hence, we speculate that the regulatory effect of acup...

This symposium was held on June 1-2, 2009 at NIH. The meeting was organized by NEI and jointly supported by NEI and NIBIB as a part of the NEI 40th Anniversary Symposia Series. The meeting brought together many of the world’s leading experts in ocular imaging technology to discuss the current state of the art in optical coherence tomography (OCT), adaptive optics (AO), fluorescence imaging, and...

PURPOSE To study mouse trabecular meshwork (TM) and to develop a murine TM cell line. METHODS Mouse TM in situ was studied by light and electron microscopy (EM). In addition, TM was isolated from the H-2K(b)-tsA58 transgenic mouse strain in which promoter sequences of the major histocompatibility complex H-2Kb class 1 gene are fused to sequences of the SV40 mutant temperature-sensitive (ts) s...

OBJECTIVE To develop and test the psychometric properties of a 25-item version of the National Eye Institute Visual Function Questionnaire (NEI VFQ-25). DESIGN Prospective observational cohort study of persons with 1 of 5 chronic eye diseases or low vision who were scheduled for nonurgent visits in ophthalmology practices and a reference sample of persons without eye disease. SETTING Eleven...

PURPOSE To evaluate the responsiveness of the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) in patients with diabetic macular edema using data from the RIDE and RISE trials. METHODS Patients were randomized to monthly intravitreal ranibizumab 0.3 mg, 0.5 mg, or sham injections for 2 years. The NEI VFQ-25 was administered at baseline and at Months 6, 12, 18, and 24. The ...

PURPOSE To determine the association between vision-related quality of life (VRQOL) and levels of visual function loss in the Early Manifest Glaucoma Trial (EMGT). METHODS Two hundred and fifty-five patients were included in the EMGT between 1993 and 1997 and followed regularly by ophthalmic examinations. A Swedish translation of the National Eye Institute Visual Function Questionnaire 25 (NE...

BACKGROUND The purpose of this study was to assess visual function and vision-related quality of life after intravitreal injection of ranibizumab (IVR) using a pro re nata regimen for the treatment of age-related macular degeneration. METHODS A prospective study of 54 eyes in 54 patients scheduled to undergo IVR for the treatment of exudative age-related macular degeneration was performed. A ...

background sivelestat is a neutrophil elastase inhibitor (nei) with positive impact on the respiratory complications in thoracic surgery. based on the findings of a recent study, nei may have a good response for avoiding ischemia reperfusion injury in liver resection. conclusions intravenous nei administration had positive impact on the postoperative inflammatory response and oxygenation while ...