CONTEXT AND OBJECTIVE Adequate management of parathyroid carcinoma apparently relates to the surgeons ability to identify it at the first operation. The objective of this paper was to evaluate the role of clinical suspicion in the management of parathyroid carcinoma. DESIGN AND SETTING Retrospective analysis of parathyroid carcinoma patients treated in Department of Head and Neck Surgery, Fac...

Parathyroid carcinoma is an uncommon cause of PTHdependent hypercalcemia. The collective published experience with this rare neoplasm has provided a distinctive clinical profile that differs in a number of respects from that of benign primary hyperparathyroidism (1–3). The distinguishing features of parathyroid carcinoma assume even greater prominence when viewed within the current context of p...

We investigated the involvement of the HRPT2 gene by loss of heterozygosity analysis and direct sequencing in a kindred with hyperparathyroidism-jaw tumor syndrome (HPT-JT) and three kindreds with familial isolated primary hyperparathyroidism (FIHP). Seven patients with sporadic parathyroid cancers and 35 with parathyroid adenomas with no family history of primary hyperparathyroidism or HPT-JT ...

We report the kindred with familial isolated hyperparathyroidism with parathyroid cancer. The proband was diagnosed as having primary hyperparathyroidism at age 43. The same disorder was also found in his daughter who had low bone mass. His son was found to have primary hyperparathyroidism by family screening. The pathological diagnosis of the resected parathyroid in both father and daughter wa...

PARATHYROID CARCINOMA IS a rare endocrine malignancy. It accounts for <1% of cases of sporadic primary hyperparathyroidism (PHPT) and is usually associated with more severe clinical manifestations than its much more common benign counterpart, parathyroid adenoma. Its course is typically indolent but progressive. The diagnosis of malignancy is often made only when local recurrence or metastases ...

BACKGROUND The aim of this study was to explore a new method to identify and protect parathyroid glands in neck lymph node dissection for patients with thyroid cancer. MATERIAL AND METHODS One hundred patients with thyroid cancer underwent total thyroidectomy combined with central neck lymph node dissection. During the operation, 50 patients receiving nano-carbon suspension were included in t...

Novel surgical applications include radioguided procedures in parathyroidectomy operations. In order to investigate the feasibility of usage of the portable gamma camera in parathyroidectomy operations; intraoperative radioguided parathyroidectomy operation was performed in three hyperparathyroidism patients with inconclusive preoperative parathyroid scintigraphy results. Intraoperative portabl...

Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4.5 × 3 × 2.5 cm cystic lesion in the lower pole of the right thyroid lobe that...

FISCHER, J.A., BLUM, J.W. & BINSWANGER, U. (1973) Acute parathyroid hormone response to epinephrine in vivo. Journal of Clinical Investigation, 52, 2434. KUKREJA, S.C., HARGIS, G.K., ROSENTHAL, I.M. & WILLIAMS, G.A. (1973) Pheochromocytoma causing excessive parathyroid hormone production and hypercalcemia. Annals of Internal Medicine, 79, 838. MILLER, S.M., SIZEMORE, G.W., SHEPS, S.G. & TYCE, G...