Fruit-set in the tomato has been shown to be dependent upon the presence of mature leaves (3). The nature of the nutritive materials supplied by the leaves has been studied by use of excised tomato flowers cultured on an agar medium to which various nutrients have been added. Of the organic acids tested, all those participating in the Krebs tricarboxylic acid cycle were found to be effective in...

To acquire the data concerning the tolerable upper intake level which prevents health problems from an excessive intake of pantothenic acid, an animal experiment was done. Rats of the Wistar strain (male, 3 wk old) were fed on a diet which contains 0%, 0.0016% (control group), 1%, or 3% calcium pantothenate for 29 d. The amount of weight increase, the food intake, and the organ weights were mea...

Bean and Hodges (1) gave a preliminary report of four young men in whom clinical disorders and metabolic faults were induced by a "diet" devoid of pantothenic acid, with omega-methylpantothenic acid, a vitamin antagonist (Figure 1). It is proposed here to describe details of the experiments, results, and some interpretations. The background for using molecular antagonists (2, 3) in human nutrit...

It had been found that pantothenic acid bound in coenzyme A and its partial degradation products is inactive in the test with Lactobacillus arabinosus.l In this connection a recent report by King, Lecher, and Cheldelin2 was of considerable interest. They isolated from heart muscle a pantothenic acid-containing factor which, with 9. suboxydans, gave a greater and faster growth response than woul...

In recent years, the nutritional importance of the vitamins has been amplified by the understanding of their metabolic function. It appears rather clearly that every vitamin functions in what may be called a distinct metabolic territory. It is shaped for a special metabolic function by its particular chemical nature. In return, the identification of this special functioning of the various chemi...

A set of chemical reactions is proposed to account for the formation of pantothenic acid derivatives from a primeval atmosphere composed of ammonia, formaldehyde, propyne, ethyne, hydrogen sulfide, hydrogen and water. Three precursor molecules are initially formed; a di-adduct of propyne and the catalyst Mg.porphin, azetidine2one, and 2-amino ethyl mercaptan. These then react sequentially to fo...

PANTOTHENIC ACID – APPLICATIONS, SYNTHESIS AND BIOSYNTHESIS (Abstract): Pantothenic acid, also known as vitamin B5 or anti-stress vitamin, is a water-soluble vitamin with various applications in pharmaceutical industry (ointments, solut ions for treating lesions and irritation of the skin or mucous membranes, multivitamin supplements tablets, capsules, effervescent tablets, chewable tablets, sy...

The present study was undertaken to investigate the hepatoprotective effect of pantothenic acid on CCl4-induced liver damage. Male Wistar rats were orally treated with pantothenic acid (0.005, 0.01, 0.025, 0.05 and 0.1 g/kg) daily, with administration of CCl4 (1 mL/kg, 50 % CCl4 in olive oil) twice a week for 28 days. The effect of pantothenic acid on serum markers (alanine aminotransferase, as...

The distribution of CoA (I), pantetheine (2, 3), and pantothenic acid (4) among a variety of natural materials is well established. However, until now, the relative amounts of these compounds present in any one substance has not been determined. Also, data on the distribution of P-pantothenic1 acid and P-pantetheine, both of which are intermediates in the biosynthesis of CoA (5), is rather meag...