Pancreatic cancer is one of common malignant neoplasms. It characterized by poor prognosis and high mortality, which mainly due to detection in an advanced stage. This review presents epidemiological clinical characteristics pancreatic cancer, as well current strategies systemic treatment disease, including first- second-line chemotherapy, molecularly targeted therapies immunotherapy.

Pancreatic neuroendocrine neoplasms (PanNENs) are rare and heterogeneous diseases that account for less than 2% of all cases pancreatic cancer only 30% digestive neoplasia, even if their incidence prevalence continue to rise globally [...]

Background: Pancreatic carcinoma is the fourth-leading cause of cancer death in the United States and due to its late presentation, only few patients would be candidates for the curative treatment of pancreactomy. Monoclonal antibodies have brought hope to targeted therapy.Objectives: To identify new biomarkers, a panel of monoclonal antibodies was genera...

cancer is uncontrolled and unrestricted growth of malignant cells in the body. it is a multifactorial disease which either heredity or environmental factors (such as nutrition, physical inactivity, alcohol, obesity, exposure to sun, environmental pollutants, infections) contribute to the incidence of cancer. in recent years, several lines of research have focused on obesity as a potent risk fac...

Objective(s): Silibinin, as an herbal compound, has anti-cancer activity. Because of low solubility of silibinin in water and body fluids, it was encapsulated in polymersome nanoparticles and its effects were evaluated on pancreatic cancer cells and cancer stem cells.Materials and Methods: MIA PaCa-2 pancreatic cancer cells were treated ...

Pancreatic exocrine insufficiency (PEI) is highly prevalent in patients with pancreatic cancer, and has substantial implications for quality of life survival. Post resection, PEI associated increased post-operative complications, longer hospital stays higher costs. Treatment enzyme replacement therapy (PERT) improves confers significant survival advantages. Despite this many cancer do not curre...

Background: Pancreatic cancer has the highest mortality rate of all major cancers. Till now, surgical resection is considered only potentially curative therapy. The aim this study was to oleuropein (Ole) as an alternative treatment for pancreatic cancer.
 Methods: First, we determined tumor-inhibitory effect Ole in cell lines and KPC mouse model. Second, employed microarray real-time polym...

We unveil for the first time that pancreatic cancer cells (PANC-1) and secreted exosomes express MUC1 bearing cancer-relevant dynamic epitopes recognized specifically by an anti-MUC1 antibody (SN-131).

malignant tumors of pancreas are usually primary neoplasms and pancreatic metastases are rare findings. we are reporting a case of squamous cell carcinoma (scc) of the esophagus with pancreatic metastasis. a 59-year old woman was admitted with chief complaint of abdominal pain and mass. she was a known case of esophageal scc since 4 years before when she had undergone transthoracic esophagectom...