Palmoplantar keratoderma is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of palms and soles. Hypothyroidism is an unusual cause of palmoplantar keratoderma, rarely reported in the literature. We report a case of a 43-year-old woman presented with a 3-month history of a diffuse palmoplantar hyperkeratosis unresponsive to topical keratolytics and...

due to increasing worldwide water pollution, fish might be a source of excessive zinc, mercury, arsenic or  manganese  intake. the  aim  of  this  study  was  to  evaluate if  fish atopy/sensitization and fish consumption behavior are associated with eczema severity and blood levels of the 4 heavy metals. one-hundred and nineteen patients with eczema and 43 patients with miscellaneous non-eczem...

Palmoplantar lichen planus is a localized and uncommon variant of lichen planus which is mostly resistant to treatment. Our purpose was to discuss all treatment modalities proposed and tested for palmoplantar lichen planus in the literature. A systematic review of the literature was conducted to evaluate evidence regarding all treatment modalities proposed and tested for palmoplantar lichen pla...

Inherited Palmoplantar Keratodermas are rare disorders of genodermatosis that are conventionally regarded as autosomal dominant in inheritance with extensive clinical and genetic heterogeneity. This is the first report of a unique autosomal recessive Inherited Palmoplantar keratoderma -sensorineural hearing loss syndrome which has not been reported before in 3 siblings of a large consanguineous...

OBJECTIVES Tumour necrosis factor (TNF) alpha inhibitors (infliximab, etanercept, adalimumab) revolutionised the treatment of autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD) and plaque psoriasis. During these treatments, cutaneous adverse effects may occur like eczema, lupus, alopecia areata or psoriasis, which represents a paradoxical ad...

Clinical Description The patient complained of multiple non-healing sores on his chest and back for 2 years. He had been taking traditional medications for more than 30 years for rheumatism and asthma. He had sought treatment from other clinics previously, and was treated with cryotherapy and excision of some of the chest lesions. These had unfortunately recurred. Clinically, he had numerous er...

Despite, the fact that palmoplantar pustulosis is still widely known by this name, it is currently regarded as a disease distinct from psoriasis. The real cause is still unknown. Septic foci have been blamed, but their removal may not cure eruptions. A case series of de novo occurrence of palmoplantar pustulosis induced by tumor necrosis factor–alpha antagonist therapy has been reported. It has...

allergic diseases are frequent in children and their prevalence and severity deffer in the different regions of the world. a number of studies have been performed to determine the factors which are effective in the incidence of these diseases. one of the drugs that might have a role in incidence or intensity of the symptoms of allergic diseases is acetaminophen. in our survey conducted with sta...

e investigated whether or not the topographic regulation of melanocyte differentiation is determined by mesenchymal–epithelial interactions via fibroblast-derived factors. The melanocyte density in palmoplantar human skin (i.e., skin on the palms and the soles) is five times lower than that found in nonpalmoplantar sites. Palmoplantar fibroblasts significantly suppressed the growth and pigmenta...

Circumscribed palmoplantar hypokeratosis is a recently recognized dermatosis and rarely reported. It was first described in 2002 and is characterized by localized loss of the horny layer in the palmoplantar area. This dermatosis is clinically presented with a sharply circumscribed, reddish and asymptomatic plaque with slightly depressed surface localized on the palms or the soles. The clinical ...