نتایج جستجو برای: pain insensitivity
تعداد نتایج: 250603 فیلتر نتایج به سال:
Congenital insensitivity to pain with anhidrosis is a rare genetic disorder of peripheral nervous system characterised by recurrent episode of unexplained fever, generalized anhidrosis, insensitivity to pain and temperature and self mutilating behavior. We are presenting a eight year old female with CIPA who have pus discharge and pathological fracture of anterior mandible .Sural nerve biopsy r...
First described in 1932 by Dearborn as 'congenital pure analgesia', congenital insensitivity to pain and anhydrosis (CIPA) or hereditary sensory and autonomic neuropathy (HSAN) type IV is an extremely rare autosomal recessive disorder. A 7-year-old female child who is an established case of congenital insensitivity to pain and anhydrosis visited the department of pediatric medicine with osteoar...
The exact nosological status of "congenital insensitivity to pain" remains in doubt. Possible pathological correlates of this clinical syndrome include sensory neuropathy, central lesions at the level of the reticular formation or dorsal horn of the spinal cord, or a central indifference to, or asymbolia for, pain. The reassessment of two members of a kindred previously reported more than 20 ye...
Pain is a word every human being can understand. Except those with congenital insensitivity to pain there is probably no human being that has completely escaped the perception of pain. Pain is an unpleasant feeling related to a physical aggression compromising the integrity of the body. It also has an emotional component that may be weak or strong. The fear of pain may be as disturbing as pain ...
Gain-of-function mutations in the human SCN11A-encoded voltage-gated Na(+) channel NaV1.9 cause severe pain disorders ranging from neuropathic pain to congenital pain insensitivity. However, the entire spectrum of the NaV1.9 diseases has yet to be defined. Applying whole-exome sequencing we here identify a missense change (p.V1184A) in NaV1.9, which leads to cold-aggravated peripheral pain in h...
Prior findings of emotional numbness (rather than distress) among socially excluded persons led the authors to investigate whether exclusion causes a far-reaching insensitivity to both physical and emotional pain. Experiments 1-4 showed that receiving an ostensibly diagnostic forecast of a lonesome future life reduced sensitivity to physical pain, as indicated by both (higher) thresholds and to...
the primary function of pain is to warn the organism against dangers threatening its integrity. pain does serve as a warning signal for impending injuries. in some people, particularly young children. pain perception has been absent. congenital intesitivity to pain with anhidrosis (cipa) is rare genetic disease characterized by absence of reaction to noxious stimuli and anhidrosis. in this revi...
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