One of the most promising vaccine candidates against the erythrocytic forms of malaria is the 19 kDa C-terminal region of the merozoite surface protein 1 (MSP1(19)). As part of our studies aimed at the development of a Plasmodium vivax malaria vaccine, we characterized the immunogenic properties of a new bacterial recombinant protein containing the P. vivax MSP1(19) and two helper T-cell epitop...

Dendritic cells (DCs) are key activators of cellular immune responses through their capacity to induce naïve T cells and sustained effector T cell responses. This capacity is a function of their superior efficiency of antigen presentation via MHC class I and class II molecules, and the expression of co-stimulatory cell surface molecules and cytokines. Maturation of DCs is induced by microbial f...

Epitope content plays a critical role in determining T-cell and antibody responses to vaccines, biomaterials, and protein therapeutics, but its effects are nonlinear and difficult to isolate. Here, molecular self-assembly is used to build a vaccine with precise control over epitope content, in order to finely tune the magnitude and phenotype of T helper and antibody responses. Self-adjuvanting ...

Background Ad5-GUCY2C-PADRE is a replication-deficient human type 5 recombinant adenovirus (Ad5) vaccine encoding guanylyl cyclase C (GUCY2C) fused to the PAn DR Epitope (PADRE). GUCY2C, a paracrine hormone receptor producing the second messenger cyclic GMP (cGMP), is selectively expressed by intestinal epithelial cells and a subset of hypothalamic neurons, but not other tissues. Importantly, G...

In this year’s INEX[1] participation, CSIRO participated in the Ad-hoc Track, contributing to three of the four given tasks, namely the Thorough Task, the Focussed Task and the Best in Context Task. In order to use CSIRO’s plain text search engine PADRE[2] we had to preprocess the collection in a similar manner to the approach taken by our group in 2002[3]. We split the documents in subdocument...

PURPOSE In multiple sclerosis (MS), a juxtacortical lesion at the border between the gray matter (GM) and subcortical white matter (WM) may often involve the GM. A recently developed, phase-weighted magnetic resonance imaging (MRI) technique "phase difference enhanced imaging (PADRE)" can delineate the GM and WM clearly due to the difference in myelin concentration. We evaluated whether PADRE i...

PURPOSE "Mag-paDRE" is a yearly prostate health public awareness program initiated by the Philippine Urological Association. This study aimed to describe the demographic and clinical data of the participants in the 2013 "Mag-paDRE" program and to identify factors that will further improve prostate health public awareness. METHODS A descriptive cross-sectional study undertaken to collect and a...

Developments in text retrieval on the AP1000 since last year's PCW are reported. The software, now called PADRE, has been entered in the competition associated with the 1994 Text Retrieval Conference (TREC-3). PADRE is now capable of document relevance estimation and ranking, and supports data loading from and dumping to the Fujitsu Local Filesystem. A new load balancing operation has been devi...

M. Roxo-Rosa*, M. Oleastro and F. F. Vale Center for Biodiversity, Functional & Integrative Genomics (BioFIG), Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal Departamento de Genética Humana, Instituto Nacional Saúde Dr. Ricardo Jorge, Av. Padre Cruz, 1649-016 Lisboa, Portugal Departamento de Doenças Infeciosas, Instituto Nacional Saúde Dr. Ricardo Jorge,...

Wilms' Tumour 1 (WT1) is a zinc finger transcription factor that is over-expressed in acute myeloid leukaemia (AML). Its restricted expression in normal tissues makes it a promising target for novel immunotherapies aiming to accentuate the cytotoxic T lymphocyte (CTL) response against AML. Here we report a phase I/II clinical trial of subcutaneous peptide vaccination with two separate HLA-A2-bi...