نتایج جستجو برای: p69

تعداد نتایج: 90  

Journal: :The Journal of Experimental Medicine 1983
S L Naylor A Y Sakaguchi T B Shows M L Law D V Goeddel P W Gray

A cDNA clone for human immune interferon (IFN-gamma) gene sequences, plasmid p69, was used to chromosomally map the IFN-gamma gene by detecting human IFN-gamma gene sequences in DNA isolated from human-rodent somatic cell hybrids. We were able to map the IFN-gamma gene by correlating the human chromosomes present in these hybrids with the human specific 8.8 and 2.0 kilobase pair fragments produ...

Journal: :Molecular cancer therapeutics 2009
Xueping Zhang Marcia V Fournier Joy L Ware Mina J Bissell Adly Yacoub Zendra E Zehner

Prostate epithelial cells grown embedded in laminin-rich extracellular matrix (lrECM) undergo morphologic changes that closely resemble their architecture in vivo. In this study, growth characteristics of three human prostate epithelial sublines derived from the same cellular lineage, but displaying different tumorigenic and metastatic properties in vivo, were assessed in three-dimensional lrEC...

Journal: :Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo 2012

2015
William T. Budd Sarah J. Seashols-Williams Gene C. Clark Danielle Weaver Valerie Calvert Emanuel Petricoin Ema A. Dragoescu Katherine O’Hanlon Zendra E. Zehner Natasha Kyprianou

MicroRNAs (miRs) are a novel class of small RNA molecules, the dysregulation of which can contribute to cancer. A combinatorial approach was used to identify miRs that promote prostate cancer progression in a unique set of prostate cancer cell lines, which originate from the parental p69 cell line and extend to a highly tumorigenic/metastatic M12 subline. Together, these cell lines are thought ...

Journal: :Journal of immunology 2001
W Chen I Bergerot J F Elliott L C Harrison N Abiru G S Eisenbarth T L Delovitch

The expression of pro(insulin) in the thymus may lead to the negative selection of pro(insulin) autoreactive T cells and peripheral tolerance to this autoantigen in type 1 diabetes (T1D). We investigated whether proinsulin is expressed in the thymus of young nonobese diabetic (NOD) mice, whether T cells from naive NOD female mice at weaning are reactive to mouse proinsulin, and the role of proi...

Journal: :Molecules 2016
Yun-Jiao Liu Cai-Yun Zhang Gang Hao Xue-Jun Ge Hai-Fei Yan

Primula poissonii (Primulaceae) is a perennial herb, widely distributed in the Hengduan Mountain region of Southwest China. In this study, Roche 454 pyrosequencing was used to isolate microsatellite markers. A total of 4528 unique sequences were identified from 68,070 unique reads. Of these, eighty-seven microsatellite loci were screened for utility using two criteria: successful PCR amplificat...

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