Objectives. To investigate whether lifestyle-only intervention in obese children who maintain or lose a modest amount of weight redistributes parameters of body composition and reverses metabolic abnormalities. Study Design. Clinical, anthropometric, and metabolic parameters were assessed in 111 overweight or obese children (CA of 11.3± 2.8 years; 63 females and 48 males), during 8 months of li...

Abstract Introduction Clinicians prescribing hypnotics remain concerned regarding the inability to discontinue after chronic use. In a controlled prospective study using self-administration choice procedures we tested whether BZRA hypnotic receptor specificity is predictive of discontinuation difficulty in clinical trial which insomnia subjects are instructed stop taking their medication 6 mont...

OBJECTIVES/HYPOTHESIS To compare clinicopathologic and prognostic factors associated with scalp melanomas and nonscalp melanomas of the head and neck (H&N). STUDY DESIGN Post hoc analysis of the database from a multi-institutional, prospective, randomized study. METHODS Clinicopathologic factors were assessed and correlated with survival and recurrence. Univariate and multivariate analysis ...

Background Serum C-terminal telopeptide of type I collagen (CTX - a marker bone resorption) and ACPA titer have been associated to higher erosive score in rheumatoid arthritis (RA) lower mineral density (BMD), even patients with pre-arthritis. Prominent inflammatory status cannot totally explain such association. The interplay between ACPA, disease activity, BMD CTX is still unclear. Objectives...

OBJECTIVE This study aimed to evaluate the clinical efficacy and antibody response changes after specific immunotherapy (SIT) using Dermatophagoides pteronyssinus (Dpt) allergens with or without bacterial extracts in Brazilian mite-atopic patients. METHODS One-hundred patients with allergic rhinitis were selected for a randomized double-blind, placebo-controlled trial and distributed into 4 g...

The effects of orally administered diltiazem combined with maximally tolerated doses of beta-blockers and nitrates were assessed in 12 patients, who during stress testing exhibited persistent effort angina and continued objective evidence for inducible myocardial ischemia. Patients performed multistage semisupine exercise on a bicycle ergometer during equilibrium-gated radionuclide angiography ...

BACKGROUND Between 30% and 50% of women who have high-grade uterine leiomyosarcoma (uLMS) limited to the uterus at diagnosis remain progression-free at 2 years. Adjuvant pelvic radiation does not improve outcome. The objective of the current study was to determine the 2-year and 3-year progression-free survival (PFS) among a prospective cohort of women who received adjuvant gemcitabine plus doc...

Young adults with ASD experience difficulties with social skills, empathy, loneliness, and social anxiety. One intervention, PEERS® for Young Adults, shows promise in addressing these challenges. The present study replicated and extended the original study by recruiting a larger sample (N = 56), employing a gold standard ASD assessment tool, and examining changes in social anxiety utilizing a r...

Twenty-five crossbred gilts were used in an experiment to determine the tryptophan (Trp) requirement for reproduction. L-tryptophan was added to a fortified corn-gelatin diet to attain the five Trp levels of .64, 1.04, 1.44, 1.84 and 2.24 g per day. These diets were fed at 2 kg daily during pregnancy I and 1.82 kg daily during pregnancies II and III. During each 3-week lactation, all animals we...

CONTEXT Few randomized controlled trials have evaluated the efficacy of treatments for major depression in patients with coronary artery disease (CAD). None have simultaneously evaluated an antidepressant and short-term psychotherapy. OBJECTIVE To document the short-term efficacy of a selective serotonin reuptake inhibitor (citalopram) and interpersonal psychotherapy (IPT) in reducing depress...