Libraries of lanthanide complexes supported by nitrogen and oxygen containing ligands have been synthesised using a high-throughput approach. The complexes were employed in the ring-opening polymerisation of epsilon-caprolactone, in some cases giving polycaprolactone of controlled molecular weight and narrow polydispersity. The libraries, based on twenty-one ligands and eight lanthanide reagent...

Heme is an iron-containing complex involved in fundamental cellular functions including oxygen transport. Free heme accumulation blood, during intravascular hemolysis and other pathological conditions, triggers vascular dysfunction, pro-inflammatory, prothrombotic cascade. Studies by May et al present a novel finding that ligand for RAGE binds to the V domain of induces oligomerization. Further...

A new decadentate dinucleating ligand containing a pyridazine bridging group and pyridylic arms has been synthesized and characterized by analytical and spectroscopic techniques. Four new dinuclear cobalt complexes featuring this ligand have been prepared and thoroughly characterized both in the solid state (X-ray diffraction) and in solution (1D and 2D NMR spectroscopy, ESI-MS, and electrochem...

The iron-containing hemoglobins (Hbs) are essential proteins to serve as oxygen transporters in the blood. Among various kinds of Hbs, the earthworm Hbs are the champions in carrying oxygen due to not only their large size but also the unusually high cooperativity of ligand binding. However, the cooperative oxygen binding mechanisms are still mostly unknown. Here we report the cryo-electron mic...

We report a 67Zn nuclear magnetic resonance (NMR) study of compounds containing zinc ions coordinated by oxygen, nitrogen, and sulfur ligands. New information concerning 67Zn nuclear quadrupole coupling constants (NQCC) and chemical shift was obtained from magic-angle spinning (MAS) spectra of solid compounds containing both natural abundance and enriched 67Zn isotopes. Rapid ligand exchange pr...

A series of Pd(II) aryl complexes a PNO-type pincer ligand bearing weakly coordinated benzofuran side arm has been prepared. Crystallographic studies showed very long Pd–O distances more than 2.3 Å, which is significantly longer the in structurally similar PNO-Pd with an exocylic oxygen donor. and 19F NMR solution containing electron-donating (OMe) electron-withdrawing (CF3) substituents positi...

We investigate the anti-cancer stem cell (CSC) properties of two copper(II) complexes containing 4,7-diphenyl-1,10-phenanthroline and a S, N, X-Schiff base ligand, where X=O (1) or S (2). Complex 1 was previously reported by us, is first metal complex to induce cytotoxic immunogenic death breast CSCs. 2 structural analogue 1, phenolate moiety (within Schiff ligand) replaced thiophenolate group....