conclusions hemodialysis exacerbates oxidative stress and conformational changes of hb in patients with diabetes on hemodialysis. the frap value can be used as a positive determinant, while pco and hb derivatives can be used as negative determinants of oxidative stress in patients with diabetes. background diabetes is associated with an increased generation of reactive oxygen species (ros), whi...

objective: hexavalent chromium [cr (vi)] compounds are well-known environmental contaminants  generated from industrial processes. several studies have reported the harmful effects of cr (vi) on different organs, however, little is known about neurotoxic effects of cr (vi). the aim of this study is to investigate the toxic effects of cr (vi) on pc12 cells. methods: pc12 cells were cultured foll...

objective(s): exposing to stress may be associated with increased production of reactive oxygen species (ros). therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. it has been presented that brain-derived neurotrophic factor (bdnf) supports neurons against various neurodegenerative conditio...

results the results revealed that metal urine concentration in welders was higher than controls but only the difference in chromium concentration was significant (p < 0.002). in the range of metals exposure, induction of oxidative stress for exposed group was observed by increase in urine mda (11.17 ± 4.23 and 4.83 ± 1.82 mm in welders and controls, respectively; p < 0.01). information of the m...

the metabolic syndrome (ms) recognized as a major cause of type 2 diabetes and cardiovascular diseases, has become one of the major public health challenges worldwide. the pathogenesis of the metabolic syndrome is multiple and still poorly understood. no single factor has yet been identified as an underlying causal factor. there is a growing belief, however, that obesity, specially visceral obe...

background : gliomas are the most common primary brain tumors of the central nervous system. among a number of different bio-molecular events, molecular connections between oxidative stress pathways and their development is prevalent. oxidative stress is the consequence of an imbalance between pro-oxidant factors and antioxidant defense. this imbalance may lead to dna damage and changes in grow...

objective: oxidative stress that damages proteins result in aging and age related diseases. the aim of this study is to determine the effect of tocotrienol rich fraction (trf) on the expression of proteins in oxidative stress-induced caenohabditis elegans (c.elegans) which has homologous genes to humans. methods: the worms were treated with trf prior to, after and continuously in separate group...

glaucoma is the second leading cause of irreversible blindness and a neurodegenerative disease with a complex pathogenesis. increasing evidence suggests that oxidative stress and mitochondrial dysfunction have crucial roles in most neurodegenerative diseases such as glaucoma. the conventional clinical treatment for glaucoma is lowering the intraocular pressure (iop). some patients have normal i...