doxorubicin (dox) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. the dose-dependent cardiotoxicity of dox significantly limits its anticancer efficacies. oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to dox mitochondr...

osteoporosis is a disease of high prevalence with increased bone loss. it has potential public health threat and that the health authorities had taken several measures for its control. in recent years, considerable attention has been given to physiopathology of osteoporosis. oxidative stress has been proved to be involved in bone resorption. oxidative stress occurs when balance between oxidants...

the study aimed to investigate the protective effects of crocin (cro) against streptozotocin (stz)-induced oxidative damage in rat striatum. animals were randomly divided into four groups (five each). group 1 (sham) were treated with normal saline (2 ml/kg, p.o.). group 2 (stz-lesioned or lesion) were injected with icv-stz (3 mg/kg bilaterally, on day 1 and 3) and treated with normal saline (2 ...

background: hawthorn species decreases blood pressure and relaxes precontracted vessels. this study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension. methods: six groups of male sprague-dawley rats, each containing 6 to 8 rats, were studied. the groups comprised of...

introduction: fasting, like islamic ramadan fasting, has been associated with health benefits. islamic ramadan fasting, a form of caloric restriction (cr) or alternate day fasting that. studies suggest a comparable effect of adf and caloric restriction. despite the fact that fasting can be considered as a form of dietary restriction, fasters tend to have difficulty to reduce their food intake d...

cirrhosis is the consequence of chronic liver disease. deleterious effects of oxidative stress on hepatocytes may be reflected in the erythrocyte membrane. naltrexone (ntx) has been shown to attenuate hepatocellular injury in fibrotic animal models. the aim of this study was to investigate the progressive effect of ccl 4 on the liver and whether the improvement of liver cirrhosis can be monitor...

objective(s): we aimed to study the effect of trimetazidine (tmz) on urethral wound repair. materials and methods: a total of 52 male rats were used; 8 groups were formed: 1-week and 3-week control (c1,c3), sham (s1, s3), oral (ot1, ot3), and intraurethral tmz (iut1, iut3) groups. serum and urine total antioxidant capacity (tac), total oxidant capacity (toc), and 8-hydroxy-deoxy-guanosine (8-oh...

objective(s):previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (stz)-induced diabetic rats. recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. howev...

aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis. recent studies suggest that aldo can cause microvascular damage, oxidative stress and endothelial dysfunction. however, its exact cellular mechanisms remain obscure. this study was undertaken to examine the effect of aldo on superoxide production in human umbilical artery endothelial cells (h...

malondialdehyde (mda) is widely used as a biomarker for assessing oxidative stress in biomedical fields. lipid peroxidation is a chain phenomenon resulting in the formation of various active compounds that result in cellular damage. biomonitoring of mda has been used in both in-vivo and in-vitro studies as a key biomarker for various disease patterns including hypertension, diabetes, atheroscle...