BACKGROUND/PURPOSE Hydrogen sulfide (H2S) is a neuromodulator acting through nitroxyl (HNO) when it reacts with nitric oxide (NO). HNO activates transient receptor potential channels of the ankyrin type 1 (TRPA1) causing release of calcitonin gene-related peptide from primary afferents. Activation of meningeal nociceptors projecting to the human spinal trigeminal nucleus (STN) may lead to heada...

The finding that potassium oxamate inhibits glycolysis by ascites tumor cells in vitro, without inhibiting oxidative metabolism (I), indicated that oxamate might be applied to the study of the role of glycolysis in tumor growth in viva. If, as Warburg (2, 3) states, tumor cells derive much of their energy for survival and growth from glycolysis, then the inhibition of glycolysis in tumor-bearin...

The heart is an important target of thyroid hormone actions. Only a limited number of cardiac target genes have been identified, and little is known about their regulation by T(3) (3,3',5-triiodothyronine) and thyroid hormone analogs. We used an oligonucleotide microarray to identify novel cardiac genes regulated by T(3) and two thyroid hormone analogs, 3,5-diidodothyropropionic acid (DITPA) an...

Oxamic acid did not inhibit oxygen utilization in intact cells or in an homogenate system of Sarcoma 37 ascites tumor cells when the concentration of inhibitor was 0.08 M or less. How ever, at higher concentrations of oxamate, it inhibited respira tion. Lactic acid production was inhibited in the intact cells and homogenate system at concentrations of oxamate as low as 0.008 M. At a concentrati...

The naturally occurring sialic acids can have different types of N- and O-substitutions, resulting in more than 20 known isomers and compounds. Most methods for the detailed study of these various sialic acids require that the molecules be first released from their alpha-glycosidic linkage. When mild acid hydrolysis is used for this purpose, significant destruction of O-substituent groups occur...

Here, the antibiotic levofloxacin (LFX) widely used and detected in environment was degraded by photoelectrolysis using a new electrode based on zinc oxide (ZnO) mixture of mixed oxides ruthenium titanium (MMO). The influence potential irradiation UV light investigated photostability Ti/MMO/ZnO degradation antibiotic. experiments were conducted at different pH values (5.0, 7.0 9.0) sodium sulfa...

Avian influenza virus stocks (A/chicken/Iran/259/1998/(H9N2)) were propagated in the allantoic cavities of 10-day-old embryonated chicken eggs. The harvested suspension was concentrated by polyethylene glycol 6000. Concentrated samples were layered onto sucrose gradient (30%-60%). Both hemagglutinin and neuraminidase were solubilized from purified viruses with Triton X-100 across 30% sucrose gr...