نتایج جستجو برای: oxadiazol denvativesl differential pulsevoltammary

تعداد نتایج: 285294  

Journal: :Journal of medicinal chemistry 2010
Marco L Lolli Cecilia Giordano Darryl S Pickering Barbara Rolando Kasper B Hansen Antonio Foti Alberto Contreras-Sanz Ahmad Amir Roberta Fruttero Alberto Gasco Birgitte Nielsen Tommy N Johansen

In order to investigate the 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as a carboxylic acid bioisoster at ionotropic glutamate receptors (iGluRs), a series of acidic alpha-aminocarboxylic acids in which the distal carboxy group was replaced by the 4-hydroxy-1,2,5-oxadiazol-3-yl group was synthesized. Ionization constants were determined. All target compounds, except the Asp analogue 12, were resolve...

Journal: :European Journal of Organic Chemistry 2021

C3-symmetrical, alkoxyphenyl substituted 2,5,8-(tris-1,3,4-oxadiazol-2-yl)benzo [1,2-b; 3,4-b′; 5,6-b′′]trithiophenes (OXD-BTT) are synthesized via threefold Huisgen-reaction. A broad variation of alkoxy substitution pattern and chain lengths is reported. The thermal behavior was investigated differential scanning calorimetry (DSC), polarized optical microscopy (POM) thermogravimetry (TGA). Opt...

2010
Franciele C. Savariz Anelise S. N. Formagio Valéria A. Barbosa Mary Ann Foglio João E. de Carvalho Marta C. T. Duarte Benedito P. Dias Filho Maria Helena Sarragiotto

Com o propósito de aumentar a atividade anticâncer demonstrada anteriormente pelas 1-fenilssubstituído-3-(2-tioxo-1,3,4-oxadiazol-5-il) b-carbolinas 1a-c, neste trabalho foram realizadas a síntese e a avaliação in vitro da atividade antitumoral de novas bases de Mannich 2-7(a-c), derivadas da introdução de diferentes grupos alquilamino(metil) na unidade 1,3,4-oxadiazol de 1a-c. Os derivados 1a-...

2014
Mohamed Jawed Ahsan Jyotika Sharma Monika Singh Surender Singh Jadav Sabina Yasmin

In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues. The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers cell lines. N-(2,4-Dimethylphenyl)-5-(4-methoxyphenyl)-1,3,4-oxad...

Journal: :Acta pharmaceutica 2008
Sonia George Manoj Kumar Parameswaran Acharjee Raja Chakraborty Thengungal Kochupappy Ravi

Reaction of ethyl-6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carboxylates (1a-i) with hydrazine hydrate yielded 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carbohydrazides (2a-i). These products, on reaction with cyanogen bromide, gave 5-(5-amino-1,3,4-oxadiazol-2-yl)-6-methyl-4-aryl-3,4-dihydropyrimidin-2 (1H)-ones (3a-i). The resultant aminooxadiazolylpyrimidinones were conde...

2014
Salahuddin Avijit Mazumder Mohammad Shaharyar

In this series, we have synthesised a new 2,5-disubstituted 1,3,4-oxadiazole in search of potential therapeutics for cancer. The anticancer activities were evaluated on a panel of 60 cell lines by the National Cancer Institute according to its own screening protocol. Out of the 24 compounds, 11 were selected and evaluated via single high dose (10(-5) M). In the next phase, two compounds have be...

2011
Hoong-Kun Fun Ching Kheng Quah Nithinchandra Balakrishna Kalluraya

The title compound, C(18)H(14)N(6)O(2)S, exists in trans and cis configurations with respect to the two acyclic C=N bonds [bond lengths = 1.2835 (9) and 1.3049 (9) Å]. The 3,6-dihydro-2H-1,3,4-thia-diazine ring adopts a half-boat conformation. The oxadiazol-3-ium ring makes dihedral angles of 53.70 (4) and 60.26 (4)° with the two phenyl rings. In the crystal, mol-ecules are linked via pairs of ...

2014
DIVYANSHU SHARMA NITIN KUMAR

A series of novel 5-[(9H-carbazol-9-yl)methyl]-N-[(substituted phenyl)(piperazin-1-yl)methyl]-1,3,4-oxadiazol-2-amines (4a–o) derivatives was synthesized by starting with carbazole, which on reaction with ethyl chloroacetate yielded ethyl 2-(9H-carbazole-9-yl)acetate (1). Compound 1 on reaction with semicarbazide followed by cyclisation with sulphuric acid gave 5-((9H-carbazole-9-yl)-1,3,4-oxad...

2011
Harish Rajak Bhupendra S. Thakur Poonam Parmar Pramod Kumar Arun K Gupta Navneet Agrawal

The search for better antimicrobial agent due to rapid appearance of multidrug resistant microorganism and antimicrobial properties of semicarbazones and 2,5-disubstituted 1,3,4-oxadiazoles prompted us to undertake the synthesis of a few novel N-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N-(4substitutedbenzaldehyde)-semicarbazone and N-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N-[1-(4s...

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