نتایج جستجو برای: oxa 48

تعداد نتایج: 144813  

Journal: :Antimicrobial agents and chemotherapy 2014
Dora E Wiskirchen Patrice Nordmann Jared L Crandon David P Nicolau

Enterobacteriaceae producing the OXA-48 carbapenemase are emerging worldwide, leaving few treatment options. Efficacy has been demonstrated in vivo with ceftazidime against a ceftazidime-susceptible OXA-48 isolate but not with imipenem despite maintaining susceptibility. The relationship between phenotype and in vivo efficacy was assessed for OXA-48 producers using humanized regimens of 2 g dor...

Journal: :The Journal of antimicrobial chemotherapy 2012
Vassiliki Dimou Hiran Dhanji Rachel Pike David M Livermore Neil Woodford

OBJECTIVES To characterize UK clinical isolates of Enterobacteriaceae producing OXA-48-like carbapenemases and to compare their resistance plasmids. METHODS Twenty-six enterobacteria producing OXA-48-like enzymes were studied. These were from 22 diverse hospitals in the UK. Isolates of Escherichia coli and Klebsiella pneumoniae were assigned to clonal lineages by multilocus sequence typing. C...

Journal: :Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 2016
Yeliz Cetinkol Arzu Altunçekiç Yildirim Murat Telli Mustafa Kerem Calgin

Infections due to carbapenem-resistant Klebsiella pneumoniae represent a growing problem nationally. In our study, we aimed to examine carbapenem-resistant K. pneumoniae with multiple resistance isolated in the intensive care unit of our hospital. Isolates were investigated for the presence of oxacillinase and metallo-beta lactamase genes with a view to determining the clonal relationship betwe...

Journal: :International journal of antimicrobial agents 2013
Claire P Thomas Luke S P Moore Nazik Elamin Michel Doumith Jiancheng Zhang Sunil Maharjan Marina Warner Claire Perry Jane F Turton Clare Johnstone Annette Jepson Neill D C Duncan Alison H Holmes David M Livermore Neil Woodford

OXA-48 β-lactamase is one of the several emerging carbapenemases. Pre-2007 reports were almost exclusively from Turkey, but subsequently its distribution has expanded. We report an early and prolonged outbreak in the UK of Klebsiella pneumoniae producing OXA-48 carbapenemase affecting a predominantly renal cohort in a West London hospital. Carbapenemase production was detected by the modified H...

Journal: :Journal of Microbiology, Immunology and Infection 2015

Journal: :Romanian Journal of Laboratory Medicine 2022

Abstract Introduction: This study provides data on carbapenemases identified in carbapenem-resistant Klebsiella pneumoniae (CR-KP) isolated from blood-cultures by the multiplex molecular method. Material and method : Between October 2016 September 2017, 47 non-duplicate (KP) were blood cultures, hospitalized patients Regional Institute of Gastroenterology Hepathology, Cluj-Napoca, Romania. Iden...

Journal: : 2022

Aim:Carbapenemase-producing organisms are Gram-negative bacteria that resistant to most, sometimes all, antibiotics with their carbapenemase enzymes. Rapid and accurate detection of carbapenemases is essential for the early prevention nosocomial infections.
 Material Method:The study included 72 isolates, 64 containing Oxa-48, 6 NDM, 2 NDM+Oxa-48 16 isolates without carbapenemase, isolated...

Journal: :Journal of Antimicrobial Chemotherapy 2012

2017
Roger Marti Roger Stephan Jochen Klumpp Magdalena Nüesch-Inderbinen Jörg Hummerjohann Claudia Bagutti Katrin Zurfluh

Here we present the complete genome sequence of Enterobacter cloacae 704SK10, a Swiss wastewater isolate encoding an OXA-48 carbapenemase. Assembly resulted in closed sequences of the 4,876,946-bp chromosome, a 111,184-bp IncF plasmid, and an OXA-48-encoding IncL plasmid (63,458 bp) nearly identical to the previously described plasmid pOXA-48.

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