Low density Polyethylene (designated hereafter as “PE”) is known for its inactivity, durability and resistance to degradation. For this reason adding pro-oxidants additives in PE matrix could be efficient elaborate a material designated Ox-PE, exhibiting chemical reactivity. This modification lead an enhancement of compatibility between Ox-PE other functionalized polymers. approach has been exp...

The syntheses and characterization of four new hybrid coordination networks based on lanthanide ions (Ln = Nd, Sm) and 1,3-carboxymethylimidazolium (L) salt in the presence of oxalic acid (H2ox) are reported. The influence of the synthesis parameters, such as the nature of the lanthanide ion (Nd3+ or Sm3+), the nature of the imidazolium source (chloride [H2L][Cl] or zwitterionic [HL] form) and ...

BACKGROUND Despite increasing appreciation that atherogenesis involves participation of inflammatory cells, information on mediators of communication between different constituents of atherosclerotic plaque remain incomplete. We examined the role of LOX-1, a receptor for oxidized (ox) LDL, in the expression of CD40/CD40L in cultured human coronary artery endothelial cells (HCAECs). METHODS AN...

BACKGROUND Macrophage death in advanced lesion has been confirmed to play an important role in plaque instability. However, the mechanism underlying lesion macrophage death still remains largely unknown. METHODS AND RESULTS Immunohistochemistry showed that caspase-1 activated in advanced lesion and co-located with macrophages and TUNEL positive reaction. In in-vitro experiments showed that ox...

This study was designed to investigate the apoptosis induced by oxidized low-density lipoprotein (ox-LDL) in cultured neonatal rat cardiomyocytes and explore the possible mechanisms. We evaluated whether ox-LDL-induced apoptosis depended in part on the activation of toll-like receptor-4(TLR4)/Nuclear factor κB (NF-κB) signaling pathway. Cells were cultivated with and without ox-LDL. Cell apopto...

The present study aimed to determine whether the expression of lectin-like oxidized LDL receptor 1 (LOX-1) could be induced by oxidized low-density lipoprotein (Ox-LDL) and interleukin 1β (IL-1β) in human mesangial cells (HMCs). Oil Red O staining was used to observe the uptake of Ox-LDL by HMCs stimulated with IL-1β, and reverse transcription-quantitative polymerase chain reaction analysis and...

The tryptophan residues of P nerve growth factor (J3NGF) were modified by reaction with varying concentrations of N-bromosuccinimide. Analysis of the oxidized derivatives by electrophoresis under denaturing conditions, before and after reduction or oxidation of disulfide bonds, revealed partial hydrolysis of specific peptide bonds. Analysis of the newly created NH2 termini by the 5-dimethylami...

OBJECTIVE Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-(5,6 epoxyisoprostanoyl)-sn-glycero-3-phosphocholine (PEIPC), which are present in atherosclerotic lesions, activate endothelial cells to induce a complex inflammatory and pro-oxidant response. Previously, we demonstrated induction of genes regulating chemotaxis, s...

Atherosclerosis is an inflammatory disease. The atherosclerosis process starts when low-density lipoproteins (LDLs) enter the intima of the blood vessel, where they are oxidized (ox-LDLs). The anti-inflammatory response triggers the recruitment of monocytes. Once in the intima, the monocytes are transformed into macrophages and foam cells, leading to the production of inflammatory cytokines and...

A new synthetic approach for the production of carbon nanomaterials (CNM) decorated with organophosphorus moieties is presented. Three different triphenylphosphine oxide (TPPO) derivatives were used to decorate oxidized multiwalled carbon nanotubes (ox-MWCNTs) and graphene platelets (GPs). The TPPOs chosen bear functional groups able to react with the CNMs by Tour reaction (an amino group), nit...