نتایج جستجو برای: ox ldl

تعداد نتایج: 33243  

Journal: :Journal of lipid research 2014
Dongxu Fu Jeremy Y Yu Mingyuan Wu Mei Du Ying Chen Souzan A Abdelsamie Yanchun Li Junping Chen Michael E Boulton Jian-Xing Ma Maria F Lopes-Virella Gabriel Virella Timothy J Lyons

Recently it has been shown that levels of circulating oxidized LDL immune complexes (ox-LDL-ICs) predict the development of diabetic retinopathy (DR). This study aimed to investigate whether ox-LDL-ICs are actually present in the diabetic retina, and to define their effects on human retinal pericytes versus ox-LDL. In retinal sections from people with type 2 diabetes, costaining for ox-LDL and ...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2001
T Kumagai T Nagata Y Kudo Y Fukuchi K Ebina K Yokota

We examined the effects of human low density lipoprotein (LDL) and oxidized LDL (Ox-LDL) on the cytotoxic activity of Asp-hemolysin from Aspergillus fumigatus Fresenius-Muramatsu strain to mouse peritoneal macrophages (M phi). The inhibitory effects of LDL and Ox-LDL on the cytotoxic activity of Asp-hemolysin to M phi increased in a dose-dependent manner, and the effect of Ox-LDL was greater th...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2001
H Kataoka N Kume S Miyamoto M Minami M Morimoto K Hayashida N Hashimoto T Kita

Oxidized low density lipoprotein (Ox-LDL) induces apoptosis in vascular smooth muscle cells (VSMCs), which may increase atherosclerotic plaque instability. In this study, we examined the molecular mechanisms causing the Ox-LDL-induced apoptosis in VSMCs, especially focusing on the involvement of Bax/Bcl-2 and the lectinlike Ox-LDL receptor-1 (LOX-1). In cultured bovine aortic smooth muscle cell...

Journal: :Journal of lipid research 1994
I Maor M Aviram

The early atherosclerotic lesion is comprised of foam cell macrophages filled with cholesteryl ester (CE), unesterified cholesterol (UC), and cholesterol oxides. Upon incubation of macrophages with oxidized low density lipoprotein (Ox-LDL), they accumulate UC rather than CE, which was shown to accumulate after incubation of cells with acetylated LDL (Ac-LDL). Using lipoproteins that were doubly...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2000
D Li J L Mehta

A specific lectin-like endothelial receptor for oxidized low density lipoprotein (LOX-1), distinct from the scavenger receptor in monocytes/macrophages, has been identified and cloned. In this study, we examined the regulation of LOX-1 by oxidized low density lipoprotein (ox-LDL) and determined the role of LOX-1 in ox-LDL-induced apoptosis of cultured human coronary artery endothelial cells (HC...

Journal: :Circulation 2000
D Li T Saldeen F Romeo J L Mehta

BACKGROUND We demonstrated earlier that angiotensin II (Ang II), by AT(1) receptor activation, upregulates oxidized LDL (ox-LDL) endothelial receptor LOX-1 gene expression and uptake of ox-LDL in human coronary artery endothelial cells (HCAECs). In this study, we investigated the regulation of Ang II receptors (AT1R and AT2R) by ox-LDL and the role of the redox-sensitive transcription factor NF...

2000
Dayuan Li Jawahar L. Mehta

A specific lectinlike endothelial receptor for oxidized low density lipoprotein (LOX-1), distinct from the scavenger receptor in monocytes/macrophages, has been identified and cloned. In this study, we examined the regulation of LOX-1 by oxidized low density lipoprotein (ox-LDL) and determined the role of LOX-1 in ox-LDL–induced apoptosis of cultured human coronary artery endothelial cells (HCA...

Journal: :iranian journal of allergy, asthma and immunology 0
azadeh mottaghi department of nutrition and biochemistry, school of public health, tehran university of medical sciences, tehran, iran. eisa salehi department of immunology, faculty of medicine, tehran university of medical sciences, tehran, iran hashem sezavar department of internal medicine, division of cardiology, school of medicine, tehran university of medical sciences, tehran, iran seyed ali keshavarz department of nutrition and biochemistry, school of public health, tehran university of medical sciences, tehran, iran mohammad reza eshraghian department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran nima rezaei research center for immunodeficiencies, pediatrics center of excellence, children's medical center, tehran university of medical sciences, tehran, iran and  department of immunology, molecular immunology research center; school of medicine,tehran university of medical sciences, tehran, iran

atherosclerosis is a chronic inflammatory condition that affects the arterial wall. oxidized low- density lipoprotein (ox-ldl) seems to have an important role in atherosclerotic plaque formation. this study was performed to investigate the effects of ox-ldl as well as pha on proliferation and gene expression of  peripheral blood  mononuclear  cells (pbmcs) in patients with atherosclerosis compa...

2013
Lizhen Liao Qin Zhou Yan Song Weikang Wu Huimin Yu Sheng Wang Yanling Chen Meihong Ye Lihe Lu

Vascular calcification is associated with significant cardiovascular morbidity and mortality, and has been demonstrated as an actively regulated process resembling bone formation. Oxidized low density lipoprotein (Ox-LDL) has been identified as a regulatory factor involved in calcification of vascular smooth muscle cells (VSMCs). Additionally, over-expression of recombinant human neutral sphing...

Journal: :Oman medical journal 2016
Medha Rajappa Devinder Mohan Thappa Laxmisha Chandrashekar Malathi Munisamy G Revathy

OBJECTIVES Psoriasis is a chronic inflammatory skin disease. Chronic inflammation results in increased oxidative stress and oxidizes lipoproteins, increasing their atherogenicity. This study sought to estimate the levels of oxidized low-density lipoprotein (ox-LDL) and antibodies against oxidized LDL (anti-ox-LDL) and compute the ratio of anti-ox-LDL/ox-LDL as a single composite parameter to as...

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