Local endometrial aberrations are thought to be the major contributing factor to essential menorrhagia. Here we have examined the role of endometrial angiogenesis, the growth of new blood vessels, in essential menorrhagia. Our study tested two hypotheses: firstly that angiogenesis is disturbed in the endometrium of women with menorrhagia; and secondly that when menstrual blood loss is decreased...

Hypovitaminosis A was found to be an important cause of menorrhagia, and a statistically significant difference between the fasting serum vitamin A values of healthy controls and patients with menorrhagia was noted. Vitamin A is a co-factor of 3 beta-dehydrogenase in steroidogenesis and deficiencies of this vitamin may result in impaired enzyme activity. The level of endogenous 17 beta-oestradi...

This study examined the effect of menorrhagia on the quality of life (QOL) of adolescents. We used data from a survey of 45 adolescents. Using the Pictorial Blood Assessment Chart (PBAC) and a PBAC score of > or =100 we identified adolescents likely to have menorrhagia. Our statistical analysis indicated that menorrhagia adversely affects the QOL of adolescents. In this article we discuss the i...

increased serum F.D.P. levels in women with clinically significant menorrhagia, as compared with those in women without abnormal menstrual symptoms. Further studies being undertaken indicate that raised serum F.D.P. levels found in women with menorrhagia are often associated with increased levels of fibrin monomer complexes in the blood. Thus raised serum F.D.P. levels in women complaining of m...

STUDY QUESTION Is the presence of adenomyosis associated with menorrhagia? SUMMARY ANSWER There was no significant association between adenomyosis and menorrhagia, but there was a significant positive correlation between the severity of adenomyosis on ultrasound and the amount of menstrual loss estimated using pictorial blood loss assessment charts. WHAT IS KNOWN ALREADY There is no consens...

The changes in the serum prolactin levels during 8 ovulatory cycles, 3 anovulatory cycles, 3 clomiphene treated cycles, 4 premarin treated cycles and 2 cycles which had just become pregnant were measured by our heterologous radioimmunoassay. Serum prolactin levels showed an increase in the ovulatory phase in 6 out of 8 ovulatory women and in the luteal phase in 5 out of 8 ovulatory women respec...

BACKGROUND Menorrhagia is objectively defined as blood loss greater than 80 ml or menstrual period lasting longer than 7 days. Dysfunctional uterine bleeding is responsible for 80% cases of Menorrhagia. Objective of this study was to find out the endometrial pathology and usefulness of hysterocopic directed endomentrial sampling in patient having menorrhagia in premenopausal age group. METHOD...

The levonorgestrel-releasing intrauterine system (LNGIUS), Mirena®, has been licensed as a contraceptive in the UK since 1995. In 2002, Mirena became licensed also for the management of idiopathic menorrhagia and in 2004 the product licence was extended further to use for “endometrial protection” to prevent endometrial hyperplasia in women receiving oestrogen replacement therapy. We report a ca...