Studies on the molecular mechanisms of transformation of retrovirus-induced neoplasms in domestic and laboratory animal species have provided insights into the genetic basis of cancer. Ovine pulmonary adenocarcinoma (OPA) is a retrovirus-induced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma. The etiologic agent of OPA, jaagsiekte sheep retrovi...

pulmonary adenocarcinoma is one of the major types of lung cancers in which metastasis is not uncommon. hereby, we report a case of pulmonary adenocarcinoma with multiple muscular, cutaneous, pancreatic and peritoneal metastases. actually, all these features occurring in one patient makes it an extraordinary case. a rare anatomic variation, double inferior vena cava (ivcs), was another rare man...

Jaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major structural protein that functions as a dominant oncoprotein. Lung cancer is the major cause of death among cancer patients. OPA can be an extremely useful animal model ...

P53 is a protein which is related to DNA, and has been called tumor suppressor, and is coded in human by the gene TP53(1). This protein plays a vital role in complex organisms, and regulates cell cycle. It functions as tumor suppressor to prevent occurrence of cancer. P53 is called genome protector or arrowhead of genome protection or head of genome watchers, all of which indicate its protectiv...

Pneumonic-type lung adenocarcinoma (P-ADC) represents a distinct subset of lung cancer with specific clinical, radiological, and pathological features. Given the weak association with tobacco-smoking and the striking similarities with jaagsiekte sheep retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma, it has been suggested that a zoonotic viral agent infecting pulmonary cells may predisp...

概要 In vivoで 肺血管外水分量(pulmonary extravascular water volume, PEV)を測 定す るこ とは,1954年Chinard & Ennsに よ り示唆 されて以来,基 礎的検討がか さね られ臨床への応用が可 能 となつた.本 論文 は,Ramseyら の方法 に準 じて後天性 心疾患に おけ るPEVを 測定 し,肺 循環諸 量,臨 床経過 お よび血液 ガス値 との関連について検 討 した ものである。測定時 の肺血管内圧 とPEV とは,粗 な正相 関(r=0.48,P<0.02)を 示 すにす ぎず,む しろPEVは 左心不全の既往 と関連 が あ る とい う結果 をえた.す なわ ち測定時 の肺 血管 内圧は同 じレベ ルにあ りなが ら,左 心不 全既往のあ る例は,既 往 のない例 に比ベ てPEVは 著 明な増加を示...

A mathematical model is used to study the dynamics of ovine brucellosis when transmitted directly from infected individual, through contact with a contaminated environment or vertically through mother to child. The model developed by Aïnseba et al. [A model for ovine brucellosis incorporating direct and indirect transmission, J. Biol. Dyn. 4 (2010), pp. 2-11. Available at http://www.math.u-bord...