1. 0. Diels and K. Alder, Justus Liebigs Ann. Chem. 460, 98 (1928); 0. Diels, J. H. Blom, W. Koll, ibid. 443, 242 (1925); B. M. Trost, I. Fleming, L. A. Paquette, Comprehensive Organic Synthesis (Pergamon, Oxford, 1991), vol. 5, pp. 316; F. Friguelli and A. Tatichi, Dienes in the Diels-Alder Reaction (Wiley, New York, 1990), and references therein; W. Carruthers, Cycloaddition Reactions in Orga...

et al. Cortical representation of ipsilateral arm movements in monkey and man. J Neuroscience 2009; 29: 12948–56. Grefkes C, Ward NS. Cortical reorganization after stroke: how much and how functional? Neuroscientist 2014; 20: 56–70. Jones TA, Allred RP, Jefferson SC, Kerr AL, Woodie DA, Cheng SY, et al. Motor system plasticity in stroke models: intrinsically use-dependent, unreliably useful. St...

A new synthetic approach has been developed for the preparation of 7-deoxypancratistatin analogues bearing a syn-(4aS,10bS)-phenanthridone ring junction. A one-pot tandem process involving a substrate-directed Overman rearrangement and ring closing metathesis reaction was developed for the stereoselective synthesis of a carbocyclic allylic trichloroacetamide. Conversion to a 6-bromopiperonyl am...

A new flexible approach for the stereoselective synthesis of substituted 1H-pyrrol-2(5H)-ones and 3,6-dihydro-1H-pyridin-2-ones has been developed. The general strategy employed the stereoselective reduction of a series of α,β-unsaturated ketones under chelation control to give the corresponding allylic alcohols. Overman rearrangement to install the key C-N bond followed by conversion to either...

All-nitrogenated sugars (ANSs), in which all hydroxy groups a carbohydrate are replaced with amino groups, anticipated to be privileged structures useful biological activities. In their Communication on page 5193, Takaaki Sato, Noritaka Chida, and co-workers report the synthesis, transformation, tests of ANS derivatives. The key success was seven-step synthesis ANSs by sequential Overman rearra...

The first total synthesis of clavaminol A and C, (2R,3S)-2-amino-3-alkanols from the Mediterranean ascidian Clavelina phlegraea has been achieved in 29% overall yield. The key step involved a palladium(II)-catalysed directed Overman rearrangement to create the C-N bond and install the erythro configuration while a one-pot, tributyltin hydride-mediated reduction allowed simultaneous formation of...

Distance-based methods for measuring spatial concentration such as the DurantonOverman index undergo an increasing popularity in the spatial econometrics community. However, a limiting factor for their usage is their computational complexity since both their memory requirements and running-time are in O(n2). In this paper, we present an algorithm with constant memory requirements and an improve...

This article examines Nietzsche’s enduring influence on Deleuze by showing how the interpretation advanced in Nietzsche and Philosophy informs Deleuze’s later work with Guattari. I analyse reading of will to power as a typology forces his Overman pinnacle creative activity an eye towards demonstrating that these are not merely Deleuzian creations but also defensible interpretations Nietzsche; s...