This study was conducted to evaluate the effect of soy milk on serum 17- β estradiol level and number of neurons in cerebral cortex and hippocampus as well as determination of the ratio of neurons in cortical and hippocampal regions in neonatal ovariectomized rats. Thirty female rats (one day old) were divided into six groups of five. At day 7, ovariectomy surgery was performed in four groups a...

Objective: The aim of this study was to investigate the possible effect of sex steroid deficiency on the rat tongue mucosa as well as the effect of its replacement. Methods: We chose 21 sexually virgin female Wistar albino rats in this study. We divided the model rats into 3 groups: Group-1:Control, Group-2: Sham-operated (bilaterally ovariectomized), and Group-3: Sham-operated, in addition we ...

BACKGROUND The fracture healing is impaired in osteoporosis. Piper sarmentosum is a plant, which contains potent antioxidant, naringenin that may enhance fracture healing. The present histological study aimed to determine the effects of water extract of Piper sarmentosum on the late phase of fracture healing in estrogen-deficient rats. METHODS Twenty four female Sprague-Dawley rats (200-250 g...

BACKGROUND Diabetes mellitus type 2 and osteoporosis are major health problem, especially in postmenopausal women. Glimepiride is a third-generation sulfonylurea derivative and is used as a first-line drug in the treatment of type 2 diabetes mellitus. The effect of this drug on bone tissue is unknown. The aim of the present study was to investigate the influence of glimepiride on the skeletal s...

BACKGROUND Osteoblasts and osteoclasts are known to express Ang II type I (AT1) receptor in cell cultures, suggesting the existence of local renin-angiotensin system (RAS) in bone. This study was designed to investigate the effects of losartan as AT1 receptor blocker on ovariectomized rats' femur. METHODS Losartan (5 mg/kg/day) was administered via oral gavage for 8 weeks. Bone mineral densit...

The present study aimed to investigate the protective and therapeutic effect of Exenatide on osteoporosis induced by ovariectomy in female Wister rats. results this showed that administration at a dose 10 mg/kg daily for 4 months led reduction symptoms ovariectomized rats, which was manifested changes serum levels bone metabolism markers (a significant increase concentration calcium, phosphorou...

background: the effects of estrogene on central nervous system are still controversial. objective: we aimed to investigate the effects of raloxifene on the antioxidant enzyme [superoxide dismutase (sod) and catalase (cat)] activities and malondialdehyde (mda) levels in brain homogenates of ovariectomized female rats and its effect on cognitive process of learning. materials and methods: female ...

Apart from having written an inglorious chapter in the history of medicine, thalidomide is currently being intensely studied because of its multidimensional activity. The aim of this study was to examine the effects of thalidomide on the skeletal system in ovariectomized and non-ovariectomized rats. The experiments were carried out with female Wistar rats, divided into eight groups: sham-operat...

Objective(s): The aim of this study was to observe the influence of phytoestrogen α-Zearalanol on ovariectomy-induced postmenopausal osteoporosis in rats. Materials and Methods:40 SD female rats were randomly divided into four groups: Sham group, OVX group (ovariectomized and fed estrogen), α-Zearalanol group (ovariectomized and fed α-Zearalanol) and untreated group (ovariectomized). Three wee...