We report a young woman with spontaneous ovarian hyperstimulation syndrome (OHSS), headaches, visual field defect and pituitary macroadenoma. She underwent transsphenoidal surgery with remission of OHSS. Immunohistochemical staining was positive for β-FSH and β-LH. Recurrence occurred after four years. The patient was treated with octreotide administration and conventional radiation therapy. Oc...

This report describes two cases that developed moderate ovarian hyperstimulation syndrome (OHSS) without evidence of haemoconcentration. Both patients developed serious cerebrovascular thrombosis resulting in hemiparesis, and recovered after treatment with anticoagulants. This report emphasizes that other factors may contribute to vascular thrombosis, and illustrates that cerebrovascular accide...

Ovarian hyperstimulation syndrome (OHSS) is still a severe complication due to controlled ovarian stimulation for artificial reproductive technology. Even though multiple techniques to avoid OHSS have been discussed in the last decades, up to now no clear concepts for primary and secondary prevention exist. This review gives an overview over proposed strategies to avoid OHSS. In a retrospective...

We report a combined intra-uterine and tubal pregnancy associated with mild ovarian hyperstimulation syndrome (OHSS) following ovulation induction by clomiphene. The diagnosis of ectopic pregnancy was originally missed until rupture occurred. OHSS confused the clinical picture, the important diagnostic feature being the fall in the haemoglobin concentration. The patient had a left partial salpi...

Ovarian hyperstimulation syndrome (OHSS) is an uncommon complication of controlled ovarian hyperstimulation. Although principal risk factors for OHSS have been determined, unfortunately, to date we are unable to precisely predict the appearance of OHSS. Still more infrequent are thromboembolic complications of OHSS. The background for the increased blood clotting in such cases includes, but is ...

The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist ...

Infertility treatment has been changed dramatically over the last decades with the introduction of the new assisted reproduction techniques (ART). Ovarian stimulation, either to induce ovulation in the management of anovulatory infertility or for controlled ovarian hyperstimulation in the course of in vitrofertilization, is a main part of the various ART. Nevertheless, ovarian stimulation entai...

Two cases of women who developed internal jugular vein (IJV) thrombosis associated with ovarian hyperstimulation syndrome (OHSS) are reported in this article. There are 27 cases of IJV thrombosis associated with in vitro fertilisation (IVF) reported in the literature, and in 78% of cases, this outcome was following OHSS. The hypercoagulable state of OHSS increases the risk of venous thromboembo...

BACKGROUND To evaluate predictive factors for recovery time from severe ovarian hyperstimulation syndrome (OHSS). METHODS In a retrospective cohort study, 201 women who were hospitalized for severe OHSS were included. Patients with recurrent OHSS were excluded. All the patients received standardized treatment including intravenous hydration, plasma volume expansion, human albumin, furosemid, ...

BACKGROUND Ovarian hyperstimulation syndrome (OHSS) is one of the most important complications of assisted reproduction treatment. Many substances are involved in the regulation of the vascular permeability, which have been concerned to cause OHSS. Vascular endothelial growth factor (VEGF) has emerged as one of the main angiogenic factors, which could be responsible for increased vascular perme...