The primordial follicle assembly, activation and the subsequent development are critical processes for female reproduction. A limited number of primordial follicles are activated to enter the growing follicle pool each wave, and the primordial follicle pool progressively diminishes over a woman's life-time. The number of remaining primordial follicles represents the ovarian reserve. Identificat...

Ovarian tumour therapy has been known to cause ovary ageing. The competitive endogenous RNA (ceRNA) network plays an indispensable role in various diseases. We constructed the ceRNA examine of circular (circRNA) ovaries older women and elucidate intervention mechanism Ziyin Buyang Formula. tissue datasets were obtained from Gene Expression Omnibus (GEO) database screened for differentially expr...

BACKGROUND Depletion of ovarian follicles is associated with the end of reproductive function in ageing females. Recently, it has been described that this process parallels increases in the concentration of norepinephrine (NE) in the rat ovary. In sexually mature rats, experimentally-induced increases in the sympathetic tone of the ovary is causally related to ovarian cyst formation and derange...

When does (sexual) ageing begin? Ageing is the natural progression of changes in structure and function that occurs with the passage of time in the absence of known disease [1] Women experience reproductive aging (hypothalamicpituitary-ovarian axis) superimposed on chronological aging. Reproductive aging begins at birth, with the progressive destruction of the oocyte’s reserve, and proceeds as ...

BACKGROUND With the occasional reports of unexpectedly poor ovarian response to controlled ovarian hyperstimulation (COH) for IVF in young normally cyclic women in mind, we studied age-related ovarian response to COH in a group of women who underwent standard IVF. METHODS Ovarian response to COH was defined as the number of follicles > or = 14 mm on the day of hCG administration. Ovarian resp...

STUDY QUESTION Is type 1 diabetes a determinant of advanced ovarian ageing, resulting in an early age at natural menopause? SUMMARY ANSWER No clear evidence was provided that type 1 diabetes is a determinant of accelerated ovarian ageing resulting in an early menopause. WHAT IS KNOWN ALREADY The association between type 1 diabetes and early menopause has been examined previously with incons...